Sökning: onr:"swepub:oai:gup.ub.gu.se/237887" > A randomized trial ...
Fältnamn | Indikatorer | Metadata |
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000 | 06743naa a2200613 4500 | |
001 | oai:gup.ub.gu.se/237887 | |
003 | SwePub | |
008 | 240910s2016 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:liu-128200 | |
024 | 7 | a https://gup.ub.gu.se/publication/2378872 URI |
024 | 7 | a https://doi.org/10.1016/j.metabol.2016.03.0122 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1282002 URI |
040 | a (SwePub)gud (SwePub)liu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Romu, Thobiasu Linköpings universitet,Medicinsk informatik,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV4 aut0 (Swepub:liu)thoro52 |
245 | 1 0 | a A randomized trial of cold-exposure on energy expenditure and supraclavicular brown adipose tissue volume in humans |
264 | 1 | b Elsevier BV,c 2016 |
500 | a Funding agencies: Linkoping University; County Council of Ostergotland (LUA-ALF), Sweden; Swedish Research Council [2013-4466, 2012-1652, 2014-2516]; Knut and Alice Wallenberg Foundation; Sahlgrenskas University Hospital (LUA-ALF); European Union grant (DIABAT) [HEALTH-F2- | |
520 | a Objective. To study if repeated cold-exposure increases metabolic rate and/or brown adipose tissue (BAT) volume in humans when compared with avoiding to freeze. Design. Randomized, open, parallel-group trial. Methods. Healthy non-selected participants were randomized to achieve cold-exposure 1 hour/day, or to avoid any sense of feeling cold, for 6 weeks. Metabolic rate (MR) was measured by indirect calorimetry before and after acute cold-exposure with cold vests and ingestion of cold water. The BAT volumes in the supraclavicular region were measured with magnetic resonance imaging (MRI). Results. Twenty-eight participants were recruited, 12 were allocated to controls and 16 to cold-exposure. Two participants in the cold group dropped out and one was excluded. Both the non-stimulated and the cold-stimulated MR were lowered within the group randomized to avoid cold (MR at room temperature from 1841 +/- 199 kCal/24 h to 1795 +/- 213 kCal/24 h, p = 0.047 cold-activated MR from 1900 +/- 150 kCal/24 h to 1793 +/- 215 kCal/24 h, p = 0.028). There was a trend towards increased MR at room temperature following the intervention in the cold-group (p = 0.052). The difference between MR changes by the interventions between groups was statistically significant (p = 0.008 at room temperature, p = 0.032 after cold-activation). In an on-treatment analysis after exclusion of two participants that reported >= 8 days without cold-exposure, supraclavicular BAT volume had increased in the cold-exposure group (from 0.0175 +/- 0.015 1 to 0.0216 +/- 0.014 1, p = 0.049). Conclusions. We found evidence for plasticity in metabolic rate by avoiding to freeze compared with cold-exposure in a randomized setting in non-selected humans. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
653 | a Brown adipose tissue | |
653 | a Cold exposure | |
653 | a Magnetic resonance imaging | |
653 | a Metabolic rate | |
653 | a water-fat mri | |
653 | a healthy humans | |
653 | a adult humans | |
653 | a identification | |
653 | a metabolism | |
653 | a Endocrinology & Metabolism | |
653 | a Brown adipose tissue; Cold exposure; Magnetic resonance imaging; Metabolic rate | |
700 | 1 | a Vavruch, C.u Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten4 aut |
700 | 1 | a Dahlqvist Leinhard, Olofu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Radiofysikavdelningen US4 aut0 (Swepub:liu)oloda24 |
700 | 1 | a Tallberg, J.u Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten4 aut |
700 | 1 | a Dahlström, Nilsu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Röntgenkliniken i Linköping4 aut0 (Swepub:liu)nilda87 |
700 | 1 | a Persson, Andersu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Röntgenkliniken i Linköping4 aut0 (Swepub:liu)andpe75 |
700 | 1 | a Heglind, Mikael,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg, Gothenburg, Sweden.4 aut0 (Swepub:gu)xhegmi |
700 | 1 | a Lidell, Martin,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg, Gothenburg, Sweden.4 aut0 (Swepub:gu)xlidma |
700 | 1 | a Enerbäck, Sven,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg, Gothenburg, Sweden.4 aut0 (Swepub:gu)xenesv |
700 | 1 | a Borga, Magnusu Linköpings universitet,Medicinsk informatik,Tekniska högskolan,Centrum för medicinsk bildvetenskap och visualisering, CMIV4 aut0 (Swepub:liu)magbo72 |
700 | 1 | a Nyström, Fredriku Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Endokrinmedicinska kliniken4 aut0 (Swepub:liu)freny92 |
710 | 2 | a Linköpings universitetb Medicinsk informatik4 org |
773 | 0 | t Metabolism-Clinical and Experimentald : Elsevier BVg 65:6, s. 926-934q 65:6<926-934x 0026-0495x 1532-8600 |
856 | 4 | u http://www.metabolismjournal.com/article/S0026049516300026/pdf |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:930096/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/237887 |
856 | 4 8 | u https://doi.org/10.1016/j.metabol.2016.03.012 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-128200 |
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