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Lactobacilli Reduce...
Lactobacilli Reduce Helicobacter pylori Attachment to Host Gastric Epithelial Cells by Inhibiting Adhesion Gene Expression
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de Klerk, N. (författare)
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Maudsdotter, L. (författare)
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Gebreegziabher, H. (författare)
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Saroj, S. D. (författare)
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Eriksson, B. (författare)
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Eriksson, O. S. (författare)
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Roos, S. (författare)
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- Lindén, Sara K., 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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Sjolinder, H. (författare)
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Jonsson, A. B. (författare)
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(creator_code:org_t)
- American Society for Microbiology, 2016
- 2016
- Engelska.
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Ingår i: Infection and Immunity. - : American Society for Microbiology. - 0019-9567 .- 1098-5522. ; 84:5, s. 1526-1535
- Relaterad länk:
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https://iai.asm.org/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The human gastrointestinal tract, including the harsh environment of the stomach, harbors a large variety of bacteria, of which Lactobacillus species are prominent members. The molecular mechanisms by which species of lactobacilli interfere with pathogen colonization are not fully characterized. In this study, we aimed to study the effect of lactobacillus strains upon the initial attachment of Helicobacter pylori to host cells. Here we report a novel mechanism by which lactobacilli inhibit adherence of the gastric pathogen H. pylori. In a screen with Lactobacillus isolates, we found that only a few could reduce adherence of H. pylori to gastric epithelial cells. Decreased attachment was not due to competition for space or to lactobacillus-mediated killing of the pathogen. Instead, we show that lactobacilli act on H. pylori directly by an effector molecule that is released into the medium. This effector molecule acts on H. pylori by inhibiting expression of the adhesin-encoding gene sabA. Finally, we verified that inhibitory lactobacilli reduced H. pylori colonization in an in vivo model. In conclusion, certain Lactobacillus strains affect pathogen adherence by inhibiting sabA expression and thereby reducing H. pylori binding capacity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- signal-transduction system
- human stomach
- in-vitro
- binding
- saba
- disease
- strain
- mucins
- model
- colonization
- Immunology
- Infectious Diseases
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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de Klerk, N.
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Maudsdotter, L.
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Gebreegziabher, ...
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Saroj, S. D.
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Eriksson, B.
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Eriksson, O. S.
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visa fler...
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Roos, S.
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Lindén, Sara K., ...
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Sjolinder, H.
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Jonsson, A. B.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Infection and Im ...
- Av lärosätet
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Göteborgs universitet