Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: onr:"swepub:oai:gup.ub.gu.se/239372" > Genome-wide associa...

1 av 1
Föregående post
Nästa post
Till träfflistan

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		08537naa a2202005 4500
001		oai:gup.ub.gu.se/239372
003		SwePub
008		240528s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:135089540
024	7	a https://gup.ub.gu.se/publication/2393722 URI
024	7	a https://doi.org/10.1093/hmg/ddw1812 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1350895402 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Hou, Liping4 aut
245	1 0	a Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.
264		c 2016-06-21
264	1	b Oxford University Press (OUP),c 2016
520		a Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behavior. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, p=5.87×10(-9); odds ratio=1.12) and markers within ERBB2 (rs2517959, p=4.53×10(-9); odds ratio=1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
700	1	a Bergen, Sarah Eu Karolinska Institutet4 aut
700	1	a Akula, Nirmala4 aut
700	1	a Song, Jieu Karolinska Institutet4 aut
700	1	a Hultman, Christina Mu Karolinska Institutet4 aut
700	1	a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xlandt
700	1	a Adli, Mazda4 aut
700	1	a Alda, Martin4 aut
700	1	a Ardau, Raffaella4 aut
700	1	a Arias, Bárbara4 aut
700	1	a Aubry, Jean-Michel4 aut
700	1	a Backlund, Lenau Karolinska Institutet4 aut
700	1	a Badner, Judith A4 aut
700	1	a Barrett, Thomas B4 aut
700	1	a Bauer, Michael4 aut
700	1	a Baune, Bernhard T4 aut
700	1	a Bellivier, Frank4 aut
700	1	a Benabarre, Antonio4 aut
700	1	a Bengesser, Susanne4 aut
700	1	a Berrettini, Wade H4 aut
700	1	a Bhattacharjee, Abesh Kumar4 aut
700	1	a Biernacka, Joanna M4 aut
700	1	a Birner, Armin4 aut
700	1	a Bloss, Cinnamon S4 aut
700	1	a Brichant-Petitjean, Clara4 aut
700	1	a Bui, Elise T4 aut
700	1	a Byerley, William4 aut
700	1	a Cervantes, Pablo4 aut
700	1	a Chillotti, Caterinau Karolinska Institutet4 aut
700	1	a Cichon, Sven4 aut
700	1	a Colom, Francesc4 aut
700	1	a Coryell, William4 aut
700	1	a Craig, David W4 aut
700	1	a Cruceanu, Cristiana4 aut
700	1	a Czerski, Piotr M4 aut
700	1	a Davis, Tony4 aut
700	1	a Dayer, Alexandre4 aut
700	1	a Degenhardt, Franziska4 aut
700	1	a Del Zompo, Maria4 aut
700	1	a DePaulo, J Raymond4 aut
700	1	a Edenberg, Howard J4 aut
700	1	a Étain, Bruno4 aut
700	1	a Falkai, Peter4 aut
700	1	a Foroud, Tatiana4 aut
700	1	a Forstner, Andreas J4 aut
700	1	a Frisén, Louiseu Karolinska Institutet4 aut
700	1	a Frye, Mark A4 aut
700	1	a Fullerton, Janice M4 aut
700	1	a Gard, Sébastien4 aut
700	1	a Garnham, Julie S4 aut
700	1	a Gershon, Elliot S4 aut
700	1	a Goes, Fernando S4 aut
700	1	a Greenwood, Tiffany A4 aut
700	1	a Grigoroiu-Serbanescu, Maria4 aut
700	1	a Hauser, Joanna4 aut
700	1	a Heilbronner, Urs4 aut
700	1	a Heilmann-Heimbach, Stefanie4 aut
700	1	a Herms, Stefan4 aut
700	1	a Hipolito, Maria4 aut
700	1	a Hitturlingappa, Shashi4 aut
700	1	a Hoffmann, Per4 aut
700	1	a Hofmann, Andrea4 aut
700	1	a Jamain, Stephane4 aut
700	1	a Jiménez, Esther4 aut
700	1	a Kahn, Jean-Pierre4 aut
700	1	a Kassem, Layla4 aut
700	1	a Kelsoe, John R4 aut
700	1	a Kittel-Schneider, Sarah4 aut
700	1	a Kliwicki, Sebastian4 aut
700	1	a Koller, Daniel L4 aut
700	1	a König, Barbara4 aut
700	1	a Lackner, Nina4 aut
700	1	a Laje, Gonzalo4 aut
700	1	a Lang, Maren4 aut
700	1	a Lavebratt, Catharina4 aut
700	1	a Lawson, William B4 aut
700	1	a Leboyer, Marion4 aut
700	1	a Leckband, Susan G4 aut
700	1	a Liu, Chunyu4 aut
700	1	a Maaser, Anna4 aut
700	1	a Mahon, Pamela B4 aut
700	1	a Maier, Wolfgang4 aut
700	1	a Maj, Mariou Karolinska Institutet4 aut
700	1	a Manchia, Mirko4 aut
700	1	a Martinsson, Linau Karolinska Institutet4 aut
700	1	a McCarthy, Michael J4 aut
700	1	a McElroy, Susan L4 aut
700	1	a McInnis, Melvin G4 aut
700	1	a McKinney, Rebecca4 aut
700	1	a Mitchell, Philip B4 aut
700	1	a Mitjans, Marina4 aut
700	1	a Mondimore, Francis M4 aut
700	1	a Monteleone, Palmiero4 aut
700	1	a Mühleisen, Thomas W4 aut
700	1	a Nievergelt, Caroline M4 aut
700	1	a Nöthen, Markus M4 aut
700	1	a Novák, Tomas4 aut
700	1	a Nurnberger, John I4 aut
700	1	a Nwulia, Evaristus A4 aut
700	1	a Ösby, Urban4 aut
700	1	a Pfennig, Andrea4 aut
700	1	a Potash, James B4 aut
700	1	a Propping, Peter4 aut
700	1	a Reif, Andreas4 aut
700	1	a Reininghaus, Eva4 aut
700	1	a Rice, John4 aut
700	1	a Rietschel, Marcella4 aut
700	1	a Rouleau, Guy A4 aut
700	1	a Rybakowski, Janusz K4 aut
700	1	a Schalling, Martin4 aut
700	1	a Scheftner, William A4 aut
700	1	a Schofield, Peter R4 aut
700	1	a Schork, Nicholas J4 aut
700	1	a Schulze, Thomas G4 aut
700	1	a Schumacher, Johannes4 aut
700	1	a Schweizer, Barbara W4 aut
700	1	a Severino, Giovanni4 aut
700	1	a Shekhtman, Tatyana4 aut
700	1	a Shilling, Paul D4 aut
700	1	a Simhandl, Christian4 aut
700	1	a Slaney, Claire M4 aut
700	1	a Smith, Erin N4 aut
700	1	a Squassina, Alessio4 aut
700	1	a Stamm, Thomas4 aut
700	1	a Stopkova, Pavla4 aut
700	1	a Streit, Fabian4 aut
700	1	a Strohmaier, Jana4 aut
700	1	a Szelinger, Szabolcs4 aut
700	1	a Tighe, Sarah K4 aut
700	1	a Tortorella, Alfonso4 aut
700	1	a Turecki, Gustavo4 aut
700	1	a Vieta, Eduard4 aut
700	1	a Volkert, Julia4 aut
700	1	a Witt, Stephanie H4 aut
700	1	a Wright, Adam4 aut
700	1	a Zandi, Peter P4 aut
700	1	a Zhang, Peng4 aut
700	1	a Zollner, Sebastian4 aut
700	1	a McMahon, Francis J4 aut
710	2	a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi4 org
773	0	t Human molecular geneticsd : Oxford University Press (OUP)g 25:15, s. 3383-94q 25:15<3383-94x 1460-2083x 0964-6906
856	4	u https://academic.oup.com/hmg/article-pdf/25/15/3383/8624729/ddw181.pdf
856	4 8	u https://gup.ub.gu.se/publication/239372
856	4 8	u https://doi.org/10.1093/hmg/ddw181
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:135089540

Hitta via bibliotek

Human molecular genetics (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Hou, Liping; Bergen, Sarah E; Akula, Nirmala; Song, Jie; Hultman, Christi ...; Landén, Mikael, ...; visa fler...; Adli, Mazda; Alda, Martin; Ardau, Raffaella; Arias, Bárbara; Aubry, Jean-Mich ...; Backlund, Lena; Badner, Judith A; Barrett, Thomas ...; Bauer, Michael; Baune, Bernhard ...; Bellivier, Frank; Benabarre, Anton ...; Bengesser, Susan ...; Berrettini, Wade ...; Bhattacharjee, A ...; Biernacka, Joann ...; Birner, Armin; Bloss, Cinnamon ...; Brichant-Petitje ...; Bui, Elise T; Byerley, William; Cervantes, Pablo; Chillotti, Cater ...; Cichon, Sven; Colom, Francesc; Coryell, William; Craig, David W; Cruceanu, Cristi ...; Czerski, Piotr M; Davis, Tony; Dayer, Alexandre; Degenhardt, Fran ...; Del Zompo, Maria; DePaulo, J Raymo ...; Edenberg, Howard ...; Étain, Bruno; Falkai, Peter; Foroud, Tatiana; Forstner, Andrea ...; Frisén, Louise; Frye, Mark A; Fullerton, Janic ...; Gard, Sébastien; Garnham, Julie S; Gershon, Elliot ...; Goes, Fernando S; Greenwood, Tiffa ...; Grigoroiu-Serban ...; Hauser, Joanna; Heilbronner, Urs; Heilmann-Heimbac ...; Herms, Stefan; Hipolito, Maria; Hitturlingappa, ...; Hoffmann, Per; Hofmann, Andrea; Jamain, Stephane; Jiménez, Esther; Kahn, Jean-Pierr ...; Kassem, Layla; Kelsoe, John R; Kittel-Schneider ...; Kliwicki, Sebast ...; Koller, Daniel L; König, Barbara; Lackner, Nina; Laje, Gonzalo; Lang, Maren; Lavebratt, Catha ...; Lawson, William ...; Leboyer, Marion; Leckband, Susan ...; Liu, Chunyu; Maaser, Anna; Mahon, Pamela B; Maier, Wolfgang; Maj, Mario; Manchia, Mirko; Martinsson, Lina; McCarthy, Michae ...; McElroy, Susan L; McInnis, Melvin ...; McKinney, Rebecc ...; Mitchell, Philip ...; Mitjans, Marina; Mondimore, Franc ...; Monteleone, Palm ...; Mühleisen, Thoma ...; Nievergelt, Caro ...; Nöthen, Markus M; Novák, Tomas; Nurnberger, John ...; Nwulia, Evaristu ...; Ösby, Urban; Pfennig, Andrea; Potash, James B; Propping, Peter; Reif, Andreas; Reininghaus, Eva; Rice, John; Rietschel, Marce ...; Rouleau, Guy A; Rybakowski, Janu ...; Schalling, Marti ...; Scheftner, Willi ...; Schofield, Peter ...; Schork, Nicholas ...; Schulze, Thomas ...; Schumacher, Joha ...; Schweizer, Barba ...; Severino, Giovan ...; Shekhtman, Tatya ...; Shilling, Paul D; Simhandl, Christ ...; Slaney, Claire M; Smith, Erin N; Squassina, Aless ...; Stamm, Thomas; Stopkova, Pavla; Streit, Fabian; Strohmaier, Jana; Szelinger, Szabo ...; Tighe, Sarah K; Tortorella, Alfo ...; Turecki, Gustavo; Vieta, Eduard; Volkert, Julia; Witt, Stephanie ...; Wright, Adam; Zandi, Peter P; Zhang, Peng; Zollner, Sebasti ...; McMahon, Francis ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

Artiklar i publikationen: Human molecular ...

Av lärosätet: Göteborgs universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se