Sökning: onr:"swepub:oai:gup.ub.gu.se/239654" > Prediction of clini...
Fältnamn | Indikatorer | Metadata |
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000 | 06637naa a2200769 4500 | |
001 | oai:gup.ub.gu.se/239654 | |
003 | SwePub | |
008 | 240910s2016 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:eb016806-2ec2-4f0f-a71e-5bbd42b83b3d | |
009 | oai:DiVA.org:uu-300104 | |
009 | oai:DiVA.org:umu-124277 | |
009 | oai:prod.swepub.kib.ki.se:133879584 | |
024 | 7 | a https://gup.ub.gu.se/publication/2396542 URI |
024 | 7 | a https://doi.org/10.1080/21681805.2016.11832262 DOI |
024 | 7 | a https://lup.lub.lu.se/record/eb016806-2ec2-4f0f-a71e-5bbd42b83b3d2 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3001042 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1242772 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1338795842 URI |
040 | a (SwePub)gud (SwePub)lud (SwePub)uud (SwePub)umud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bjartell, Andersu Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups,Skåne University Hospital,Skane Univ Hosp, Dept Urol, SE-20502 Malmo, Sweden.;Lund Univ, Div Urol Canc, Dept Translat Med, S-22100 Lund, Sweden.4 aut0 (Swepub:lu)kir-abj |
245 | 1 0 | a Prediction of clinical progression after radical prostatectomy in a nationwide population-based cohort |
264 | c 2016-05-18 | |
264 | 1 | b Medical Journals Sweden AB,c 2016 |
520 | a Objective: The aim of this study was to create a model for predicting progression-free survival after radical prostatectomy for localized prostate cancer. Material and methods: The risk of biochemical recurrence (BCR) was modelled in a cohort of 3452 men aged 70 years or younger who were primarily treated with radical prostatectomy after being diagnosed between 2003 and 2006 with localized prostate cancer [clinical stage T1c-T2, Gleason score 5-10, N0/NX, M0/MX, prostate-specific antigen (PSA)<20 ng/ml]. The cohort was split into two: one cohort for model development (n = 3452) and one for validation (n = 1762). BCR was defined as two increasing PSA values of at least 0.2 ng/ml, initiation of secondary therapy, distant metastases or death from prostate cancer. Multivariable Cox proportional hazard regression was applied, predictive performance was assessed using the bootstrap resampling technique to calculate the c index, and calibration of the model was evaluated by comparing predicted and observed Kaplan-Meier 1 year BCR. Results: The overall 5 year progression-free survival was 83% after a median follow-up time of 6.8 years in the development cohort and 7.3 years in the validation cohort. The final model included T stage, PSA level, primary and secondary Gleason grade, and number of positive and negative biopsies. The c index for discrimination between high and low risk of recurrence was 0.68. The probability of progression-free survival ranged from 22% to 97% over the range of risk scores in the study population. Conclusions: This model is based on nationwide population-based data and can be used with a fair predictive accuracy to guide decisions on clinical follow-up after prostatectomy. An online calculator for convenient clinical use of the model is available at www.npcr.se/nomogram | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
653 | a Biochemical recurrence | |
653 | a nomogram | |
653 | a predictive models | |
653 | a prostate cancer | |
653 | a radical prostatectomy | |
653 | a university-of-california | |
653 | a risk-assessment score | |
653 | a biochemical recurrence | |
653 | a preoperative nomogram | |
653 | a external validation | |
653 | a 10-year probability | |
653 | a disease | |
653 | a recurrence | |
653 | a cancer recurrence | |
653 | a san-francisco | |
653 | a sweden | |
653 | a Urology & Nephrology | |
653 | a Biochemical recurrence | |
700 | 1 | a Bottai, M.u Karolinska Institutet,Karolinska Inst, Inst Environm Med, Unit Biostat, Stockholm, Sweden.4 aut |
700 | 1 | a Persson, J.u Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Dept Cardiothorac Surg, Gothenburg, Sweden.4 aut |
700 | 1 | a Bratt, Olau Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups,University of Cambridge,Lund Univ, Div Urol Canc, Dept Translat Med, S-22100 Lund, Sweden.;Cambridge Univ Hosp, Dept Urol, Cambridge, England.4 aut0 (Swepub:lu)urok-obr |
700 | 1 | a Damber, Jan-Erik,d 1949u University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Univ Gothenburg, Inst Clin Sci Sahlgrenska Acad, Dept Urol, Gothenburg, Sweden.4 aut0 (Swepub:gu)xdamja |
700 | 1 | a Stattin, Päru Umeå universitet,Uppsala universitet,Umeå University,Urologkirurgi,Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden.,Urologi och andrologi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:umu)past0003 |
700 | 1 | a Akre, O.u Karolinska Institutet4 aut |
710 | 2 | a Urologisk cancerforskning, Malmöb Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Scandinavian Journal of Urologyd : Medical Journals Sweden ABg 50:4, s. 255-259q 50:4<255-259x 2168-1805x 2168-1813 |
856 | 4 | u http://dx.doi.org/10.1080/21681805.2016.1183226y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/239654 |
856 | 4 8 | u https://doi.org/10.1080/21681805.2016.1183226 |
856 | 4 8 | u https://lup.lub.lu.se/record/eb016806-2ec2-4f0f-a71e-5bbd42b83b3d |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300104 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-124277 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133879584 |
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