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Sökning: onr:"swepub:oai:gup.ub.gu.se/241421" > A/T/N: An unbiased ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003557naa a2200421 4500
001oai:gup.ub.gu.se/241421
003SwePub
008240528s2016 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2414212 URI
0247 a https://doi.org/10.1212/WNL.00000000000029232 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Jack, Clifford R4 aut
2451 0a A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers.
264 1c 2016
520 a Biomarkers have become an essential component of Alzheimer disease (AD) research and because of the pervasiveness of AD pathology in the elderly, the same biomarkers are used in cognitive aging research. A number of current issues suggest that an unbiased descriptive classification scheme for these biomarkers would be useful. We propose the "A/T/N" system in which 7 major AD biomarkers are divided into 3 binary categories based on the nature of the pathophysiology that each measures. "A" refers to the value of a β-amyloid biomarker (amyloid PET or CSF Aβ42); "T," the value of a tau biomarker (CSF phospho tau, or tau PET); and "N," biomarkers of neurodegeneration or neuronal injury ([(18)F]-fluorodeoxyglucose-PET, structural MRI, or CSF total tau). Each biomarker category is rated as positive or negative. An individual score might appear as A+/T+/N-, or A+/T-/N-, etc. The A/T/N system includes the new modality tau PET. It is agnostic to the temporal ordering of mechanisms underlying AD pathogenesis. It includes all individuals in any population regardless of the mix of biomarker findings and therefore is suited to population studies of cognitive aging. It does not specify disease labels and thus is not a diagnostic classification system. It is a descriptive system for categorizing multidomain biomarker findings at the individual person level in a format that is easy to understand and use. Given the present lack of consensus among AD specialists on terminology across the clinically normal to dementia spectrum, a biomarker classification scheme will have broadest acceptance if it is independent from any one clinically defined diagnostic scheme.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
7001 a Bennett, David A4 aut
7001 a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka
7001 a Carrillo, Maria C4 aut
7001 a Feldman, Howard H4 aut
7001 a Frisoni, Giovanni B4 aut
7001 a Hampel, Harald4 aut
7001 a Jagust, William J4 aut
7001 a Johnson, Keith A4 aut
7001 a Knopman, David S4 aut
7001 a Petersen, Ronald C4 aut
7001 a Scheltens, Philip4 aut
7001 a Sperling, Reisa A4 aut
7001 a Dubois, Bruno4 aut
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
7730 t Neurologyg 87:5, s. 539-47q 87:5<539-47x 1526-632X
8564 8u https://gup.ub.gu.se/publication/241421
8564 8u https://doi.org/10.1212/WNL.0000000000002923

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