Sökning: onr:"swepub:oai:gup.ub.gu.se/242393" > Asymmetric Inherita...
Fältnamn | Indikatorer | Metadata |
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000 | 04858naa a2200541 4500 | |
001 | oai:gup.ub.gu.se/242393 | |
003 | SwePub | |
008 | 240910s2016 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2423932 URI |
024 | 7 | a https://doi.org/10.1016/j.celrep.2016.06.0162 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hill, Sandra Malmgren,d 1987u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för kemi och molekylärbiologi,Institute of Biomedicine,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xmalms |
245 | 1 0 | a Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions |
264 | 1 | b Elsevier BV,c 2016 |
520 | a Age can be reset during mitosis in both yeast and stem cells to generate a young daughter cell from an aged and deteriorated one. This phenomenon requires asymmetry-generating genes (AGGs) that govern the asymmetrical inheritance of aggregated proteins. Using a genome-wide imaging screen to identify AGGs in Saccharomyces cerevisiae, we discovered a previously unknown role for endocytosis, vacuole fusion, and the myosin-dependent adaptor protein Vac17 in asymmetrical inheritance of misfolded proteins. Overproduction of Vac17 increases deposition of aggregates into cytoprotective vacuole-associated sites, counteracts age-related breakdown of endocytosis and vacuole integrity, and extends replicative lifespan. The link between damage asymmetry and vesicle trafficking can be explained by a direct interaction between aggregates and vesicles. We also show that the protein disaggregase Hsp104 interacts physically with endocytic vesicle-associated proteins, such as the dynamin-like protein, Vps1, which was also shown to be required for Vac17-dependent sequestration of protein aggregates. These data demonstrate that two physiognomies of aging-reduced endocytosis and protein aggregation-are interconnected and regulated by Vac17. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
653 | a life-span | |
653 | a saccharomyces-cerevisiae | |
653 | a damaged proteins | |
653 | a misfolded | |
653 | a proteins | |
653 | a actin cytoskeleton | |
653 | a quality-control | |
653 | a budding yeast | |
653 | a v-atpase | |
653 | a fusion | |
653 | a chaperone | |
653 | a Cell Biology | |
700 | 1 | a Hao, Xinxinu Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Institutionen för biomedicin,Department of Chemistry and Molecular Biology,Institute of Biomedicine4 aut0 (Swepub:gu)xxinha |
700 | 1 | a Grönvall, Johanu Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut |
700 | 1 | a Spikings-Nordby, Stephanieu Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut |
700 | 1 | a Widlund, Per Ou Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för kemi och molekylärbiologi,Institute of Biomedicine,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xwidlp |
700 | 1 | a Amen, T.4 aut |
700 | 1 | a Jorhov, Annau Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut |
700 | 1 | a Josefson, Rebeccau Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för kemi och molekylärbiologi,Institute of Biomedicine,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xlinre |
700 | 1 | a Kaganovich, D.4 aut |
700 | 1 | a Liu, Beidong,d 1972u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xbeili |
700 | 1 | a Nyström, Thomas,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institutionen för kemi och molekylärbiologi,Institute of Biomedicine,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xnysth |
710 | 2 | a Göteborgs universitetb Institutionen för biomedicin4 org |
773 | 0 | t Cell Reportsd : Elsevier BVg 16:3, s. 826-838q 16:3<826-838x 2211-1247 |
856 | 4 | u http://www.cell.com/article/S2211124716307562/pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/242393 |
856 | 4 8 | u https://doi.org/10.1016/j.celrep.2016.06.016 |
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