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Precursor B Cells I...
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Samitas, Konstantinos,1977Gothenburg University,Göteborgs universitet,Krefting Research Centre
(författare)
Precursor B Cells Increase in the Lung during Airway Allergic Inflammation: A Role for B Cell-Activating Factor
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2016-08-11
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Public Library of Science (PLoS),2016
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/243174
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https://gup.ub.gu.se/publication/243174URI
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https://doi.org/10.1371/journal.pone.0161161DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:134151738URI
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Background B cells, key cells in allergic inflammation, differentiate in the bone marrow and their precursors include pro-B, pre-B and immature B cells. Eosinophil progenitor cells increase in the lung after allergen exposure. However, the existence and possible role of B cell precursors in the lung during allergic inflammation remains elusive. A BALB/c mouse model of allergic airway inflammation was utilized to perform phenotypic and quantification analyses of pro-B and pre-B cells in the lung by flow cytometry. B cell maturation factors IL-7 and B cell-activating factor (BAFF) and their receptors (CD127 and BAFFR, BCMA, TACI, respectively) were also evaluated in the lung and serum. The effect of anti-BAFF treatment was investigated both in vivo (i.p. administration of BAFF-R-Ig fusion protein) and in vitro (colony forming cell assay). Finally, BAFF levels were examined in the bronchoalveolar lavage (BAL) of asthmatic patients and healthy controls. Precursor pro and pre-B cells increase in the lung after allergen exposure, proliferate in the lung tissue in vivo, express markers of chemotaxis (CCR10 and CXCR4) and co-stimulation (CD40, CD86) and are resistant to apoptosis (Bax). Precursor B cells express receptors for BAFF at baseline, while after allergen challenge both their ligand BAFF and the BCMA receptor expression increases in B cell precursors. Blocking BAFFR in the lung in vivo decreases eosinophils and proliferating precursor B cells. Blocking BAFFR in bone marrow cultures in vitro reduces pre-B colony formation units. BAFF is increased in the BAL of severe asthmatics. Our data support the concept of a BAFF-mediated role for B cell precursors in allergic airway inflammation.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Malmhäll, Carina,1959Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xmalmc
(författare)
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Rådinger, Madeleine,1967Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xradim
(författare)
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Ramos-Ramírez, PatriciaGothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xrampa
(författare)
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Lu, You,1982Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xluyow
(författare)
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Deák, Tünde,1983Gothenburg University,Göteborgs universitet,Krefting Research Centre
(författare)
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Semitekolou, M.
(författare)
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Gaga, M.
(författare)
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Sjöstrand, Margareta,1947Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xsjosm
(författare)
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Lötvall, Jan,1956Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xlotja
(författare)
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Bossios, Apostolos,1969Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xbosap
(författare)
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Göteborgs universitetKrefting Research Centre
(creator_code:org_t)
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Ingår i:Plos One: Public Library of Science (PLoS)11:81932-6203
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Samitas, Konstan ...
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Malmhäll, Carina ...
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Rådinger, Madele ...
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Ramos-Ramírez, P ...
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Lu, You, 1982
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Deák, Tünde, 198 ...
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Semitekolou, M.
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Gaga, M.
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Sjöstrand, Marga ...
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Lötvall, Jan, 19 ...
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Bossios, Apostol ...
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