Folate and MMA predict cognitive impairment in elderly stroke survivors: A cross sectional study

• Elderly stroke survivors are at risk of malnutrition and long-term cognitive impairment. Vitamin B-related metabolites, folate and methylmalonic acid, have been implicated in cognitive function. We conducted a study exploring the relationship between blood folate, methylmalonic acid and post-stroke cognitive impairment. This is a cross sectional study of elderly Swedish patients (n=149) 20 months post-stroke, assessed using the Mini Mental State Examination, serum blood levels of methylmalonic acid and red blood cell levels of folate. Linear modeling indicated that low levels of blood folate and elevated methylmalonic acid significantly contributed to cognitive impairment in stroke survivors. Half of the stroke survivors were shown to have folate deficiency at 20 months after stroke. Folate deficiency is common long term after stroke and both low folate and elevated methylmalonic acid appear to be associated with long term cognitive impairment, in elderly Swedish stroke survivors. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

Cognition

Ischemia

Nutrition

Geriatric

white-matter lesions

folic-acid supplementation

coronary-artery-disease

methylmalonic acid

rotterdam scan

clinical

determinants

endothelial function

controlled-trial

homocysteine

dementia

Psychiatry

temichi tk

1994

journal of neurology neurosurgery and psychiatry

v57

p202

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)