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FältnamnIndikatorerMetadata
00009861naa a2200901 4500
001oai:gup.ub.gu.se/243527
003SwePub
008240528s2016 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-111792
009oai:DiVA.org:uu-299060
0247 a https://gup.ub.gu.se/publication/2435272 URI
0247 a https://doi.org/10.1016/j.jaci.2015.09.0372 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1117922 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2990602 URI
040 a (SwePub)gud (SwePub)umud (SwePub)uu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Amaral, A. F. S.u Univ London Imperial Coll Sci Technol & Med, Resp Epidemiol Occupat Med & Publ Hlth, Natl Heart & Lung Inst, Emmanuel Kaye Bldg,1B Manresa Rd, London SW3 6LR, England.4 aut
2451 0a Changes in IgE sensitization and total IgE levels over 20 years of follow-up
264 1b Elsevier BV,c 2016
520 a Background Cross-sectional studies have reported a lower prevalence of sensitization in older adults, but few longitudinal studies have examined whether this is an aging or a year-of-birth cohort effect. Objective We sought to assess changes in sensitization and total IgE levels in a cohort of European adults as they aged over a 20-year period. Methods Levels of serum specific IgE to common aeroallergens (house dust mite, cat, and grass) and total IgE levels were measured in 3206 adults from 25 centers in the European Community Respiratory Health Survey on 3 occasions over 20 years. Changes in sensitization and total IgE levels were analyzed by using regression analysis corrected for potential differences in laboratory equipment and by using inverse sampling probability weights to account for nonresponse. Results Over the 20-year follow-up, the prevalence of sensitization to at least 1 of the 3 allergens decreased from 29.4% to 24.8% (-4.6%; 95% CI, -7.0% to -2.1%). The prevalence of sensitization to house dust mite (-4.3%; 95% CI, -6.0% to -2.6%) and cat (-2.1%; 95% CI, -3.6% to -0.7%) decreased more than sensitization to grass (-0.6%; 95% CI, -2.5% to 1.3%). Age-specific prevalence of sensitization to house dust mite and cat did not differ between year-of-birth cohorts, but sensitization to grass was most prevalent in the most recent ones. Overall, total IgE levels decreased significantly (geometric mean ratio, 0.63; 95% CI, 0.58-0.68) at all ages in all year-of-birth cohorts. Conclusion Aging was associated with lower levels of sensitization, especially to house dust mite and cat, after the age of 20 years. © 2015 The Authors. Published by Elsevier, Inc. on behalf ofthe American Academy of Allergy, Asthma&Immunology. This is an open access article under the CC BY license.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskapx Gerontologi, medicinsk/hälsovetenskaplig inriktning0 (SwePub)305022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciencesx Gerontology, specialising in Medical and Health Sciences0 (SwePub)305022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653 a aging
653 a Allergens
653 a cohort study
653 a epidemiology
653 a IgE
653 a immunosenescence
653 a longitudinal analysis
653 a sensitization
653 a Allergens
7001 a Newson, R. B.u Univ London Imperial Coll Sci Technol & Med, Resp Epidemiol Occupat Med & Publ Hlth, Natl Heart & Lung Inst, Emmanuel Kaye Bldg,1B Manresa Rd, London SW3 6LR, England.;Univ London Imperial Coll Sci Technol & Med, Dept Primary Care & Publ Hlth, Sch Publ Hlth, London, England.,Univ Turin, Dept Publ Hlth & Pediat, Turin, Italy.4 aut
7001 a Abramson, M. J.u Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic 3004, Australia.,Univ Hosp Huelva, Unit Clin Management Pneumol & Allergy, Huelva, Spain.4 aut
7001 a Antó, J. M.u Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.;IMIM Hosp del Mar, Med Res Inst, Barcelona, Spain.;UPF, Barcelona, Spain.;CIBERESP, Madrid, Spain.4 aut
7001 a Bono, R.4 aut
7001 a Corsico, A. G.u Univ Pavia, Div Resp Dis, IRCCS Policlin San Matteo Fdn, Via Palestro 3, I-27100 Pavia, Italy.4 aut
7001 a de Marco, R.u Univ Verona, Unit Epidemiol & Med Stat, Dept Publ Hlth & Community Med, I-37100 Verona, Italy.4 aut
7001 a Demoly, P.u CHU Montpellier, Dept Pulmonol, Div Allergy, Arnaud de Villeneuve Hosp, Paris, France.;INSERM, EPAR Team, UMR S 1136, Paris, France.4 aut
7001 a Forsberg, Bertilu Umeå universitet,Yrkes- och miljömedicin,Arcum,Umea Univ, Div Occupat & Environm Med, Dept Publ Hlth & Clin Med, Umea, Sweden.4 aut0 (Swepub:umu)befo0001
7001 a Gislason, T.u Univ Iceland, Fac Med, Reykjavik, Iceland.;Natl Univ Hosp Iceland, Landspitali, Dept Resp Med & Sleep, Reykjavik, Iceland.4 aut
7001 a Heinrich, J.u Helmholtz Zentrum, Inst Epidemiol 1, Munich, Germany.;Univ Munich, Inst & Outpatient Clin Occupat Social & Environm, Inner City Clin, Univ Hosp Munich, Munich, Germany.4 aut
7001 a Huerta, I.u Dept Hlth Asturias, Directorate Gen Publ Hlth, Epidemiol Surveillance Sect, Oviedo, Spain.4 aut
7001 a Janson, Christeru Uppsala universitet,Lungmedicin och allergologi4 aut0 (Swepub:uu)chrisjn
7001 a Jogi, Rainu Uppsala universitet,Lung- allergi- och sömnforskning,Tartu Univ Hosp, Lung Clin, Tartu, Estonia.4 aut0 (Swepub:uu)raijo735
7001 a Kim, Jeong-Limu Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Dept Publich Hlth & Community Med, Sahlgrenska Acad, Gothenburg, Sweden.4 aut0 (Swepub:gu)xkimje
7001 a Maldonado, J.4 aut
7001 a Martinez-Moratalla Rovira, J.u Univ Hosp Albacete, Unit Pneumol, Albacete, Spain.4 aut
7001 a Neukirch, C.u INSERM, UMR1152, Paris, France.;Univ Paris 07, UMR1152, Paris, France.4 aut
7001 a Nowak, D.u Univ Munich, Inst & Outpatient Clin Occupat Social & Environm, Inner City Clin, Univ Hosp Munich, Munich, Germany.;German Ctr Lung Res, Munich, Germany.4 aut
7001 a Pin, I.u CHU Grenoble, Pole Couple Enfants, Pediat, F-38043 Grenoble, France.;Inst Albert Bonniot, INSERM, U823, Grenoble, France.;Univ Grenoble 1, Grenoble, France.4 aut
7001 a Probst-Hensch, N.u Swiss Trop & Publ Hlth Inst, Basel, Switzerland.;Univ Basel, Basel, Switzerland.4 aut
7001 a Raherison-Semjen, C.u Bordeaux Univ, Inst Publ Hlth & Epidemiol, INSERM, U897, Bordeaux, France.4 aut
7001 a Svanes, C.u Univ Bergen, Ctr Int Hlth, Bergen, Norway.;Haukeland Hosp, Dept Occupat Med, N-5021 Bergen, Norway.4 aut
7001 a Urrutia Landa, I.u Galdakao Hosp, Dept Pneumol, Bizkaia, Spain.4 aut
7001 a Van Ree, R.u Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.;Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.4 aut
7001 a Versteeg, S. A.u Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.4 aut
7001 a Weyler, J.u Univ Antwerp, Epidemiol & Social Med, B-2020 Antwerp, Belgium.;Univ Antwerp, StatUA Stat Ctr, B-2020 Antwerp, Belgium.4 aut
7001 a Zock, J. P.u Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.;UPF, Barcelona, Spain.;CIBERESP, Madrid, Spain.4 aut
7001 a Burney, P. G. J.u Univ London Imperial Coll Sci Technol & Med, Resp Epidemiol Occupat Med & Publ Hlth, Natl Heart & Lung Inst, Emmanuel Kaye Bldg,1B Manresa Rd, London SW3 6LR, England.4 aut
7001 a Jarvis, D. L.u Univ London Imperial Coll Sci Technol & Med, Resp Epidemiol Occupat Med & Publ Hlth, Natl Heart & Lung Inst, Emmanuel Kaye Bldg,1B Manresa Rd, London SW3 6LR, England.4 aut
7102 a Univ London Imperial Coll Sci Technol & Med, Resp Epidemiol Occupat Med & Publ Hlth, Natl Heart & Lung Inst, Emmanuel Kaye Bldg,1B Manresa Rd, London SW3 6LR, England.b Univ London Imperial Coll Sci Technol & Med, Resp Epidemiol Occupat Med & Publ Hlth, Natl Heart & Lung Inst, Emmanuel Kaye Bldg,1B Manresa Rd, London SW3 6LR, England.;Univ London Imperial Coll Sci Technol & Med, Dept Primary Care & Publ Hlth, Sch Publ Hlth, London, England.4 org
7730 t Journal of Allergy and Clinical Immunologyd : Elsevier BVg 137:6q 137:6x 0091-6749x 1097-6825
8564 u http://www.jacionline.org/article/S009167491501430X/pdf
8564 u https://umu.diva-portal.org/smash/get/diva2:873183/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1016/j.jaci.2015.09.037y Fulltext
8564 8u https://gup.ub.gu.se/publication/243527
8564 8u https://doi.org/10.1016/j.jaci.2015.09.037
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111792
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-299060

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