Sökning: onr:"swepub:oai:gup.ub.gu.se/248530" > Genetic Evidence fo...
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000 | 07649naa a2201381 4500 | |
001 | oai:gup.ub.gu.se/248530 | |
003 | SwePub | |
008 | 240528s2016 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2485302 URI |
024 | 7 | a https://doi.org/10.1001/jama.2016.19752 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Tyrrell, Jessica4 aut |
245 | 1 0 | a Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. |
264 | 1 | b American Medical Association (AMA),c 2016 |
520 | a Neonates born to overweight or obese women are larger and at higher risk of birth complications. Many maternal obesity-related traits are observationally associated with birth weight, but the causal nature of these associations is uncertain.To test for genetic evidence of causal associations of maternal body mass index (BMI) and related traits with birth weight.Mendelian randomization to test whether maternal BMI and obesity-related traits are potentially causally related to offspring birth weight. Data from 30,487 women in 18 studies were analyzed. Participants were of European ancestry from population- or community-based studies in Europe, North America, or Australia and were part of the Early Growth Genetics Consortium. Live, term, singleton offspring born between 1929 and 2013 were included.Genetic scores for BMI, fasting glucose level, type 2 diabetes, systolic blood pressure (SBP), triglyceride level, high-density lipoprotein cholesterol (HDL-C) level, vitamin D status, and adiponectin level.Offspring birth weight from 18 studies.Among the 30,487 newborns the mean birth weight in the various cohorts ranged from 3325 g to 3679 g. The maternal genetic score for BMI was associated with a 2-g (95% CI, 0 to 3 g) higher offspring birth weight per maternal BMI-raising allele (P=.008). The maternal genetic scores for fasting glucose and SBP were also associated with birth weight with effect sizes of 8 g (95% CI, 6 to 10 g) per glucose-raising allele (P=7×10(-14)) and -4 g (95% CI, -6 to -2 g) per SBP-raising allele (P=1×10(-5)), respectively. A 1-SD (≈4 points) genetically higher maternal BMI was associated with a 55-g higher offspring birth weight (95% CI, 17 to 93 g). A 1-SD (≈7.2 mg/dL) genetically higher maternal fasting glucose concentration was associated with 114-g higher offspring birth weight (95% CI, 80 to 147 g). However, a 1-SD (≈10 mm Hg) genetically higher maternal SBP was associated with a 208-g lower offspring birth weight (95% CI, -394 to -21 g). For BMI and fasting glucose, genetic associations were consistent with the observational associations, but for systolic blood pressure, the genetic and observational associations were in opposite directions.In this mendelian randomization study, genetically elevated maternal BMI and blood glucose levels were potentially causally associated with higher offspring birth weight, whereas genetically elevated maternal SBP was potentially causally related to lower birth weight. If replicated, these findings may have implications for counseling and managing pregnancies to avoid adverse weight-related birth outcomes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
653 | a Adult | |
653 | a Birth Weight | |
653 | a genetics | |
653 | a Blood Glucose | |
653 | a genetics | |
653 | a Blood Pressure | |
653 | a genetics | |
653 | a Body Mass Index | |
653 | a Diabetes Mellitus | |
653 | a Type 2 | |
653 | a genetics | |
653 | a European Continental Ancestry Group | |
653 | a Fasting | |
653 | a blood | |
653 | a Female | |
653 | a Genotype | |
653 | a Humans | |
653 | a Infant | |
653 | a Newborn | |
653 | a Mendelian Randomization Analysis | |
653 | a Obesity | |
653 | a blood | |
653 | a ethnology | |
653 | a genetics | |
653 | a Polymorphism | |
653 | a Single Nucleotide | |
653 | a Pregnancy | |
653 | a Triglycerides | |
653 | a genetics | |
700 | 1 | a Richmond, Rebecca C4 aut |
700 | 1 | a Palmer, Tom M4 aut |
700 | 1 | a Feenstra, Bjarke4 aut |
700 | 1 | a Rangarajan, Janani4 aut |
700 | 1 | a Metrustry, Sarah4 aut |
700 | 1 | a Cavadino, Alana4 aut |
700 | 1 | a Paternoster, Lavinia4 aut |
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700 | 1 | a Wood, Andrew R4 aut |
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700 | 1 | a Melbye, Mads4 aut |
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700 | 1 | a Nodzenski, Michael4 aut |
700 | 1 | a Reichetzeder, Christoph4 aut |
700 | 1 | a Ring, Susan M4 aut |
700 | 1 | a Sebert, Sylvain4 aut |
700 | 1 | a Sengpiel, Verena,d 1977u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xsenve |
700 | 1 | a Sørensen, Thorkild I A4 aut |
700 | 1 | a Willemsen, Gonneke4 aut |
700 | 1 | a de Geus, Eco J C4 aut |
700 | 1 | a Martin, Nicholas G4 aut |
700 | 1 | a Spector, Tim D4 aut |
700 | 1 | a Power, Christine4 aut |
700 | 1 | a Järvelin, Marjo-Riitta4 aut |
700 | 1 | a Bisgaard, Hans4 aut |
700 | 1 | a Grant, Struan F A4 aut |
700 | 1 | a Nohr, Ellen A4 aut |
700 | 1 | a Jaddoe, Vincent W4 aut |
700 | 1 | a Jacobsson, Bo,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xjacbo |
700 | 1 | a Murray, Jeffrey C4 aut |
700 | 1 | a Hocher, Berthold4 aut |
700 | 1 | a Hattersley, Andrew T4 aut |
700 | 1 | a Scholtens, Denise M4 aut |
700 | 1 | a Davey Smith, George4 aut |
700 | 1 | a Hivert, Marie-France4 aut |
700 | 1 | a Felix, Janine F4 aut |
700 | 1 | a Hyppönen, Elina4 aut |
700 | 1 | a Lowe, William L4 aut |
700 | 1 | a Frayling, Timothy M4 aut |
700 | 1 | a Lawlor, Debbie A4 aut |
700 | 1 | a Freathy, Rachel M4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org |
773 | 0 | t JAMAd : American Medical Association (AMA)g 315:11, s. 1129-40q 315:11<1129-40x 1538-3598x 0098-7484 |
856 | 4 | u https://jamanetwork.com/journals/jama/articlepdf/2503173/joi160019.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/248530 |
856 | 4 8 | u https://doi.org/10.1001/jama.2016.1975 |
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