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Mast Cells Density ...
Mast Cells Density Positive to Tryptase Correlate with Microvascular Density in both Primary Gastric Cancer Tissue and Loco-Regional Lymph Node Metastases from Patients That Have Undergone Radical Surgery
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Ammendola, M. (författare)
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Sacco, R. (författare)
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Zuccala, V. (författare)
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Luposella, M. (författare)
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Patruno, R. (författare)
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Gadaleta, P. (författare)
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Zizzo, N. (författare)
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Gadaleta, C. D. (författare)
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De Sarro, G. (författare)
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Sammarco, G. (författare)
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- Oltean, Mihai, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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Ranieri, G. (författare)
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(creator_code:org_t)
- 2016-11-15
- 2016
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1422-0067. ; 17:11
- Relaterad länk:
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https://www.mdpi.com...
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Mast Cells (MCs) play a role in immune responses and more recently MCs have been involved in tumoral angiogenesis. In particular MCs can release tryptase, a potent in vivo and in vitro pro-angiogenic factor via proteinase-activated receptor-2 (PAR-2) activation and mitogen-activated protein kinase (MAPK) phosphorylation. MCs can release tryptase following c-Kit receptor activation. Nevertheless, no data are available concerning the relationship among MCs Density Positive to Tryptase (MCDPT) and Microvascular Density (MVD) in both primary gastric cancer tissue and loco-regional lymph node metastases. A series of 75 GC patients with stage T2-3N2-3M0 (by AJCC for Gastric Cancer Seventh Edition) undergone to radical surgery were selected for the study. MCDPT and MVD were evaluated by immunohistochemistry and by image analysis system and results were correlated each to other in primary tumor tissue and in metastatic lymph nodes harvested. Furthermore, tissue parameters were correlated with important clinico-pathological features. A significant correlation between MCDPT and MVD was found in primary gastric cancer tissue and lymph node metastases. Pearson t-test analysis (r ranged from 0.74 to 0.79; p-value ranged from 0.001 to 0.003). These preliminary data suggest that MCDPT play a role in angiogenesis in both primary tumor and in lymph node metastases from GC. We suggest that MCs and tryptase could be further evaluated as novel targets for anti-angiogenic therapies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- angiogenesis
- mast cells
- tryptase
- prognostic factor
- gastric cancer
- therapy
- protease-activated receptor-2
- endothelial growth-factor
- colorectal-cancer
- breast-cancer
- translational significance
- tumor
- lymphangiogenesis
- macrophages correlate
- pancreatic-cancer
- colon-cancer
- in-vivo
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ammendola, M.
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Sacco, R.
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Zuccala, V.
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Luposella, M.
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Patruno, R.
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Gadaleta, P.
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visa fler...
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Zizzo, N.
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Gadaleta, C. D.
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De Sarro, G.
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Sammarco, G.
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Oltean, Mihai, 1 ...
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Ranieri, G.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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International Jo ...
- Av lärosätet
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Göteborgs universitet