Sökning: onr:"swepub:oai:gup.ub.gu.se/249365" >
On the formation of...
On the formation of a side product with hexahydroaporphine-like structure in the Grewe cyclization of dextromethorphan
-
Zhao, Qiao (författare)
-
Zhao, Kai (författare)
-
- Wu, Sheng ying (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
-
visa fler...
-
Tian, Bo xue (författare)
-
- Eriksson, Leif A, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
-
Wang, Li min (författare)
-
An, Na (författare)
-
Long, Zhong zhu (författare)
-
Cai, Shui hong (författare)
-
visa färre...
-
(creator_code:org_t)
- 2016-09-16
- 2017
- Engelska.
-
Ingår i: Research on Chemical Intermediates. - : Springer Science and Business Media LLC. - 0922-6168 .- 1568-5675. ; 43:3, s. 1689-1708
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Factors leading to the formation of a hexahydroaporphine-like cyclizing side product were studied systematically for the first time and the ratio of this side product was controlled effectively. To understand better the electronic effect of substrates on the formation of side products, different 1-benzyloctahydroisoquinolines with substituted groups on nitrogen or benzene ring were compared. A plausible mechanism of cyclizing reaction was proposed, and key intermediates as well as transition states were analyzed using DFT calculations.
Ämnesord
- NATURVETENSKAP -- Kemi -- Teoretisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Theoretical Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- Dextromethorphan
- DFT calculation
- Grewe cyclization
- Hexahydroaporphine-like side product
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas