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Autocrine endotheli...
Autocrine endothelial regulation in brain stem vessels of newborn piglets.
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Lange, D (författare)
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- Funa, Keiko, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för anatomi och cellbiologi,Institute of Anatomy and Cell Biology
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Ishisaki, A (författare)
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visa fler...
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Bauer, R (författare)
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Wollina, U (författare)
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visa färre...
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(creator_code:org_t)
- 1999
- 1999
- Engelska.
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Ingår i: Histology and histopathology. - 0213-3911. ; 14:3, s. 821-5
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- Vasoactive intestinal peptide (VIP) is known as a potent regulator for the development of the central nervous system (CNS). The neonatal period of brain development is characterised by rapid cellular proliferation in parallel with neuronal differentiation and angiogenesis. We examined the expression of native VIP and the VIP receptor-associated protein by immunohistochemistry as well as the expression of VIP mRNA by in situ hybridisation in the brain stem of newborn piglets. We found both the mRNA and the protein of VIP as well as the VIP receptor-associated protein in endothelial cells of veins, arteries and capillaries in the marginal zone of brain stem tissue sections, especially in pons and mesencephalon, as well as in pial vessels. The coexpression of native VIP, VIP mRNA and the VIP receptor-associated protein within the endothelium suggests the presence of an autocrine loop, which has been detected so far only in neuroblastoma cells. This expression pattern gives evidence to the immaturity of endothelial cells at birth and the presence of an adaptive response in the VIP-regulated system during the change from intra- to extrauterine life.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Animals
- Animals
- Newborn
- Brain Stem
- blood supply
- Endothelium
- Vascular
- metabolism
- Gene Expression
- Receptors
- Vasoactive Intestinal Peptide
- metabolism
- Swine
- Vasoactive Intestinal Peptide
- biosynthesis
- genetics
- metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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