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Cranial irradiation...
Cranial irradiation induces transient microglia accumulation, followed by long-lasting inflammation and loss of microglia
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- Han, W. (författare)
- Karolinska Institutet
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Umekawa, T. (författare)
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- Zhou, K. (författare)
- Karolinska Institutet
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visa fler...
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- Zhang, X. M. (författare)
- Karolinska Institutet
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- Ohshima, M. (författare)
- Karolinska Institutet
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- Dominguez, C. A. (författare)
- Karolinska Institutet
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- Harris, R. A. (författare)
- Karolinska Institutet
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- Zhu, Changlian, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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- Blomgren, K. (författare)
- Karolinska Institutet
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visa färre...
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(creator_code:org_t)
- 2016-10-26
- 2016
- Engelska.
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 7:50, s. 82305-82323
- Relaterad länk:
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http://www.oncotarge...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The relative contribution of resident microglia and peripheral monocyte-derived macrophages in neuroinflammation after cranial irradiation is not known. A single dose of 8 Gy was administered to postnatal day 10 (juvenile) or 90 (adult) CX3CR1(GFP/+) CCR2(RFP/+) mouse brains. Microglia accumulated in the subgranular zone of the hippocampal granule cell layer, where progenitor cell death was prominent. The peak was earlier (6 h vs. 24 h) but less pronounced in adult brains. The increase in juvenile, but not adult, brains was partly attributed to proliferation. Microglia numbers then decreased over time to 39% (juvenile) and 58% (adult) of controls 30 days after irradiation, largely as a result of cell death. CD68 was expressed in 90% of amoeboid microglia in juvenile hippocampi but only in 9% of adult ones. Isolated hippocampal microglia revealed reduced CD206 and increased IL1-beta expression after irradiation, more pronounced in juvenile brains. CCL2 and IL-1 beta increased after irradiation, more in juvenile hippocampi, and remained elevated at all time points. In summary, microglia activation after irradiation was more pronounced, protracted and pro-inflammatory by nature in juvenile than in adult hippocampi. Common to both ages was long-lasting inflammation and the absence of monocyte-derived macrophages.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- irradiation
- neurogenesis
- neuroinflammation
- microglia
- monocyte
- macrophage
- monocyte chemoattractant protein-1
- young-mouse brain
- adult hippocampal
- neurogenesis
- fractalkine receptor cx(3)cr1
- progenitor-cell
- cognitive
- function
- rat-brain
- radiation
- activation
- neuroinflammation
- Oncology
- Cell Biology
- wler jf
- 1989
- british journal of radiology
- v62
- p679
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Han, W.
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Umekawa, T.
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Zhou, K.
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Zhang, X. M.
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Ohshima, M.
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Dominguez, C. A.
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visa fler...
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Harris, R. A.
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Zhu, Changlian, ...
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Blomgren, K.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Oncotarget
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet