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Type 1 diabetes mel...
Type 1 diabetes mellitus
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- Katsarou, Anastasia (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Gudbjörnsdottir, Soffia, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Sahlgrenska University Hospital,Sweden National Diabetes Register
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- Rawshani, Araz, 1986 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Sweden National Diabetes Register,Sahlgrenska University Hospital
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- Dabelea, D. (författare)
- Colorado School of Public Health
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- Bonifacio, E. (författare)
- Dresden University of Technology
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- Anderson, B. J. (författare)
- Texas Children’s Hospital
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- Jacobsen, L. M. (författare)
- University of Florida
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- Schatz, D. A. (författare)
- University of Florida
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- Lernmark, Ake (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2017-03-30
- 2017
- Engelska.
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Ingår i: Nature Reviews Disease Primers. - : Springer Science and Business Media LLC. - 2056-676X. ; 3
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease characterized by insulin deficiency due to pancreatic beta-cell loss and leads to hyperglycaemia. Although the age of symptomatic onset is usually during childhood or adolescence, symptoms can sometimes develop much later. Although the aetiology of T1DM is not completely understood, the pathogenesis of the disease is thought to involve T cell-mediated destruction of beta-cells. Islet-targeting autoantibodies that target insulin, 65 kDa glutamic acid decarboxylase, insulinoma-associated protein 2 and zinc transporter 8 - all of which are proteins associated with secretory granules in beta-cells -are biomarkers of T1DM-associated autoimmunity that are found months to years before symptom onset, and can be used to identify and study individuals who are at risk of developing T1DM. The type of autoantibody that appears first depends on the environmental trigger and on genetic factors. The pathogenesis of T1DM can be divided into three stages depending on the absence or presence of hyperglycaemia and hyperglycaemia-associated symptoms (such as polyuria and thirst). A cure is not available, and patients depend on lifelong insulin injections; novel approaches to insulin treatment, such as insulin pumps, continuous glucose monitoring and hybrid closed-loop systems, are in development. Although intensive glycaemic control has reduced the incidence of microvascular and macrovascular complications, the majority of patients with T1DM are still developing these complications. Major research efforts are needed to achieve early diagnosis, prevent beta-cell loss and develop better treatment options to improve the quality of life and prognosis of those affected.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- quality-of-life
- glutamic-acid decarboxylase
- randomized
- controlled-trial
- beta-cell function
- generation sequencing reveals
- american-heart-association
- hypoglycemic brain-damage
- population-based
- cohort
- infiltrating t-cells
- body-mass index
- General & Internal Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Katsarou, Anasta ...
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Gudbjörnsdottir, ...
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Rawshani, Araz, ...
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Dabelea, D.
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Bonifacio, E.
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Anderson, B. J.
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visa fler...
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Jacobsen, L. M.
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Schatz, D. A.
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Lernmark, Ake
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Nature Reviews D ...
- Av lärosätet
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Göteborgs universitet
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Lunds universitet