Sökning: onr:"swepub:oai:gup.ub.gu.se/253543" >
Relationship betwee...
Relationship between Cognitive and Sleep-wake Variables in Asymptomatic Offspring of Patients with Late-onset Alzheimer's Disease
-
- Abulafia, C. (författare)
- FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina / Applied Neuroscience Laboratory, Institute for Biomedical Research, School of Medical Sciences, Universidad Católica Argentina, Buenos Aires, Argentina / Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
-
- Duarte-Abritta, B. (författare)
- FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina
-
- Villarreal, M. F. (författare)
- FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina / Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
-
visa fler...
-
- Ladron-de-Guevara, M. S. (författare)
- FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina / Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
-
- Garcia, C. (författare)
- FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina
-
- Sequeyra, G. (författare)
- FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina
-
- Sevlever, G. (författare)
- FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina
-
- Fiorentini, L. (författare)
- FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina
-
- Bar, K. J. (författare)
- Department of Psychiatry and Psychotherapy, Universitätsklinikum Jena, Friedrich-Schiller-Universität, Jena, Germany
-
- Gustafson, Deborah, 1966 (författare)
- Högskolan i Skövde,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Department of Neurology, State University of New York, Downstate Medical Center, Brooklyn, NY, USA / Neuropsychiatric Epidemiology Unit, University of Gothenburg, Gothenburg, Sweden,Individ och samhälle (VIDSOC), Individual and Society
-
- Vigo, D. E. (författare)
- Applied Neuroscience Laboratory, Institute for Biomedical Research, School of Medical Sciences, Universidad Católica Argentina, Buenos Aires, Argentina / Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
-
- Guinjoan, S. M. (författare)
- FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina / Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina / FLENI Teaching Unit, Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine, Buenos Aires, Argentina / Department of Neurophysiology, University of Buenos Aires School of Psychology, Buenos Aires, Argentina
-
visa färre...
-
(creator_code:org_t)
- 2017-04-05
- 2017
- Engelska.
-
Ingår i: Frontiers in Aging Neuroscience. - : Frontiers Media SA. - 1663-4365. ; 9
- Relaterad länk:
-
https://www.frontier...
-
visa fler...
-
https://doi.org/10.3...
-
https://his.diva-por... (primary) (Raw object)
-
https://gup.ub.gu.se...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Early neuropathological changes characteristic of late-onset Alzheimer's disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer's disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep-wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 +/- 0.4 vs. 8.6 +/- 0.6, t = 4.97, df = 49, p < 0.01) and language (Weschler's vocabulary 51.4 +/- 1.3 vs. 44.3 +/- 1.5, t = 2.49, df = 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 +/- 0.47 h vs. 3.8 +/- 0.26 h, t = 2.48, df = 40, p = 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep-wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- early diagnosis
- late-onset Alzheimer's disease
- circadian rhythms
- cardiac autonomic control
- heart-rate-variability
- circadian system
- temperature
- network
- brain
- state
- tau
- early diagnosis
- Individual and Society VIDSOC
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Abulafia, C.
-
Duarte-Abritta, ...
-
Villarreal, M. F ...
-
Ladron-de-Guevar ...
-
Garcia, C.
-
Sequeyra, G.
-
visa fler...
-
Sevlever, G.
-
Fiorentini, L.
-
Bar, K. J.
-
Gustafson, Debor ...
-
Vigo, D. E.
-
Guinjoan, S. M.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
- SAMHÄLLSVETENSKAP
-
SAMHÄLLSVETENSKA ...
-
och Psykologi
- Artiklar i publikationen
-
Frontiers in Agi ...
- Av lärosätet
-
Göteborgs universitet
-
Högskolan i Skövde