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PDE2A2 regulates mi...
PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling.
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Monterisi, Stefania (författare)
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Lobo, Miguel J (författare)
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Livie, Craig (författare)
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visa fler...
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Castle, John C (författare)
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Weinberger, Michael (författare)
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Baillie, George (författare)
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Surdo, Nicoletta C (författare)
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Musheshe, Nshunge (författare)
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Stangherlin, Alessandra (författare)
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Gottlieb, Eyal (författare)
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Maizels, Rory (författare)
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Bortolozzi, Mario (författare)
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- Micaroni, Massimo, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Core Facilities, Centre for Cellular Imaging,Core Facilities, Centre for Cellular Imaging
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Zaccolo, Manuela (författare)
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visa färre...
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(creator_code:org_t)
- 2017
- 2017
- Engelska.
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Ingår i: eLife. - 2050-084X. ; 6
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.7...
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Abstract
Ämnesord
Stäng
- cAMP/PKA signalling is compartmentalised with tight spatial and temporal control of signal propagation underpinning specificity of response. The cAMP-degrading enzymes, phosphodiesterases (PDEs), localise to specific subcellular domains within which they control local cAMP levels and are key regulators of signal compartmentalisation. Several components of the cAMP/PKA cascade are located to different mitochondrial sub-compartments, suggesting the presence of multiple cAMP/PKA signalling domains within the organelle. The function and regulation of these domains remain largely unknown. Here, we describe a novel cAMP/PKA signalling domain localised at mitochondrial membranes and regulated by PDE2A2. Using pharmacological and genetic approaches combined with real-time FRET imaging and high resolution microscopy, we demonstrate that in rat cardiac myocytes and other cell types mitochondrial PDE2A2 regulates local cAMP levels and PKA-dependent phosphorylation of Drp1. We further demonstrate that inhibition of PDE2A, by enhancing the hormone-dependent cAMP response locally, affects mitochondria dynamics and protects from apoptotic cell death.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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eLife
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Till lärosätets databas
- Av författaren/redakt...
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Monterisi, Stefa ...
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Lobo, Miguel J
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Livie, Craig
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Castle, John C
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Weinberger, Mich ...
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Baillie, George
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visa fler...
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Surdo, Nicoletta ...
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Musheshe, Nshung ...
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Stangherlin, Ale ...
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Gottlieb, Eyal
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Maizels, Rory
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Bortolozzi, Mari ...
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Micaroni, Massim ...
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Zaccolo, Manuela
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Cellbiologi
- Artiklar i publikationen
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eLife
- Av lärosätet
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Göteborgs universitet