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Is the intake of se...
Is the intake of selective serotonin reuptake inhibitors associated with an increased risk of dental implant failure?
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- Chrcanovic, Bruno (författare)
- Malmö högskola,Odontologiska fakulteten (OD),Biofilms Research Center for Biointerfaces
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Kisch, J. (författare)
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- Albrektsson, Tomas, 1945 (författare)
- Malmö högskola,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Odontologiska fakulteten (OD),Biofilms Research Center for Biointerfaces
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visa fler...
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- Wennerberg, Ann (författare)
- Malmö högskola,Odontologiska fakulteten (OD),Biofilms Research Center for Biointerfaces
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: International Journal of Oral and Maxillofacial Surgery. - : Elsevier BV. - 0901-5027 .- 1399-0020. ; 46:6, s. 782-788
- Relaterad länk:
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http://www.ijoms.com...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The aim of this retrospective study was to investigate the association between the intake of selective serotonin reuptake inhibitors (SSRIs) and the risk of dental implant failure. Patients were included if they were taking SSRIs only and no other medication, did not present any other systemic condition or compromising habits (bruxism, smoking, snuff), and complied with the use of prophylactic antibiotics for implant surgery. The multivariate generalized estimating equation (GEE) method and multilevel mixed-effects parametric survival analysis were used to test the association between SSRI exposure (predictor variable) and the risk of implant failure (outcome variable), adjusting for several potential confounders (other variables). The total number of implants with information available and meeting the necessary eligibility criteria was 931(35 failures). These were placed in 300 patients. The implant failure rate was 12.5% for SSRI users and 3.3% for nonusers (P = 0.007). Kaplan-Meier analysis showed a statistically significant difference in the cumulative survival rate (P < 0.001). The multivariate GEE model did not show a statistically significant association between SSRI intake and implant failure (P = 0.530), nor did the multilevel model (P = 0.125). It is suggested that the intake of SSRIs may not be associated with an increased risk of dental implant failure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- dental implant
- implant failure
- selective serotonin reuptake inhibitors
- multivariate generalized
- bone-mineral density
- systemic factors
- superficial characteristics
- abutment connection
- oral implants
- periodontitis
- metaanalysis
- transporter
- impact
- antidepressants
- Dental implant
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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