Sökning: onr:"swepub:oai:gup.ub.gu.se/254869" > C-terminal fragment...
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000 | 03305naa a2200481 4500 | |
001 | oai:gup.ub.gu.se/254869 | |
003 | SwePub | |
008 | 240910s2017 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2548692 URI |
024 | 7 | a https://doi.org/10.1038/s41598-017-02841-72 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Garcia-Ayllon, M. S.4 aut |
245 | 1 0 | a C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease |
264 | c 2017-05-30 | |
264 | 1 | b Springer Science and Business Media LLC,c 2017 |
520 | a This study assesses whether C-terminal fragments (CTF) of the amyloid precursor protein (APP) are present in cerebrospinal fluid (CSF) and their potential as biomarkers for Alzheimer's disease (AD). Immunoprecipitation and simultaneous assay by Western blotting using multiplex fluorescence imaging with specific antibodies against particular domains served to characterize CTFs of APP in human CSF. We demonstrate that APP-CTFs are detectable in human CSF, being the most abundant a 25-kDa fragment, probably resulting from proteolytic processing by eta- secretase. The level of the 25-kDa APP-CTF was evaluated in three independent CSF sample sets of patients and controls. The CSF level of this 25-kDa CTF is higher in subjects with autosomal dominant AD linked to PSEN1 mutations, in demented Down syndrome individuals and in sporadic AD subjects compared to age-matched controls. Our data suggest that APP-CTF could be a potential diagnostic biomarker for AD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a BETA | |
653 | a RECOMMENDATIONS | |
653 | a AGGREGATION | |
653 | a ASSOCIATION | |
653 | a DIAGNOSIS | |
653 | a BODIES | |
653 | a CELLS | |
700 | 1 | a Lopez-Font, I.4 aut |
700 | 1 | a Boix, C. P.4 aut |
700 | 1 | a Fortea, J.4 aut |
700 | 1 | a Sanchez-Valle, R.4 aut |
700 | 1 | a Lleo, A.4 aut |
700 | 1 | a Molinuevo, J. L.4 aut |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Saez-Valero, J.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Scientific Reportsd : Springer Science and Business Media LLCg 7q 7x 2045-2322 |
856 | 4 | u https://www.nature.com/articles/s41598-017-02841-7.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/254869 |
856 | 4 8 | u https://doi.org/10.1038/s41598-017-02841-7 |
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