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omega-3 and omega-6...
omega-3 and omega-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases
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Gong, Y. (författare)
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Fu, Z. J. (författare)
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Liegl, R. (författare)
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Chen, J. (författare)
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- Hellström, Ann, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Smith, L. E. H. (författare)
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165. ; 106:1, s. 16-26
- Relaterad länk:
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Neovascular eye diseases, including retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration, threaten the visual health of children and adults. Current treatment options, including anti-vascular endothelial growth factor therapy and laser retinal photocoagulation, have limitations and are associated with adverse effects; therefore, the identification of additional therapies is highly desirable. Both clinical and experimental studies show that dietary omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFAs) reduce retinal and choroidal angiogenesis. The omega-3 LC-PUFA metabolites from 2 groups of enzymes, cyclooxygenases and lipoxygenases, inhibit [and the omega-6 (n-6) LC-PUFA metabolites promote] inflammation and angiogenesis. However, both of the omega-3 and the omega-6 lipid products of cytochrome P450 oxidase 2C promote neovascularization in both the retina and choroid, which suggests that inhibition of this pathway might be beneficial. This review summarizes our current understanding of the roles of omega-3 and omega-6 LC-PUFAs and their enzymatic metabolites in neovascular eye diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- lipid metabolism
- long-chain polyunsaturated fatty acid
- retinopathy of prematurity
- diabetic retinopathy
- age-related macular degeneration
- polyunsaturated fatty-acids
- vascular endothelial-cells
- proliferative
- diabetic-retinopathy
- randomized controlled-trial
- macular degeneration
- docosahexaenoic acid
- choroidal neovascularization
- preterm infants
- lipid mediators
- growth-factor
- Nutrition & Dietetics
- evens mk
- 1988
- journal of cerebral blood flow and metabolism
- v8
- p790
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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