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Sökning: onr:"swepub:oai:gup.ub.gu.se/255977" > PET Tau and Amyloid...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003516naa a2200433 4500
001oai:gup.ub.gu.se/255977
003SwePub
008240528s2017 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2559772 URI
0247 a https://doi.org/10.3233/JAD-1701292 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Koychev, Ivan4 aut
2451 0a PET Tau and Amyloid-β Burden in Mild Alzheimer's Disease: Divergent Relationship with Age, Cognition, and Cerebrospinal Fluid Biomarkers.
264 1c 2017
520 a Combining PET amyloid-β (Aβ) and tau imaging may be critical for tracking disease progression in Alzheimer's disease (AD).We sought to characterize the relationship between Aβ and tau ligands as well as with other measures of pathology.We conducted a multi-center observational study in early AD (MMSE >20) participants aged 50 to 85y. The schedule included cognitive assessments (ADAS-Cog) and CSF measurement of Aβ and tau at baseline and 6 months; PET-CT imaging with Aβ ([18F]AV45) and tau ([18F]AV1451) ligands at baseline.22 participants took part in the study with 20 completing its 6-month duration and 12 having both tau and amyloid PET. The PET biomarker analysis revealed a strong negative correlation between age and tau in multiple regions. Entorhinal cortex tau and age interacted significantly in terms of cognitive change over 6 months which may have been to older participants deteriorating faster despite lower levels of cortical tau. Cortical Aβ associated with entorhinal cortex tau while CSF tau/Aβ ratio correlated strongly with cortical tau but not Aβ.The negative relationship between age and cortical tau whereby younger patients with mild AD had relatively greater tau burden is potentially important. It suggests that younger-age onset AD may be primarily driven by tau pathology while AD developing later may depend on a multitude of pathological mechanisms. These data also suggest that PET-tau performs better than PET-amyloid in predicting the best validated AD diagnostic marker- the CSF total tau/Aβ ratio.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
7001 a Gunn, Roger N4 aut
7001 a Firouzian, Azadeh4 aut
7001 a Lawson, Jennifer4 aut
7001 a Zamboni, Giovanna4 aut
7001 a Ridha, Basil4 aut
7001 a Sahakian, Barbara J4 aut
7001 a Rowe, James B4 aut
7001 a Thomas, Alan4 aut
7001 a Rochester, Lynn4 aut
7001 a Ffytche, Dominic4 aut
7001 a Howard, Robert4 aut
7001 a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe
7001 a MacKay, Clare4 aut
7001 a Lovestone, Simon4 aut
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
7730 t Journal of Alzheimer's disease : JADg 60:1, s. 283-293q 60:1<283-293x 1875-8908
8564 8u https://gup.ub.gu.se/publication/255977
8564 8u https://doi.org/10.3233/JAD-170129

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