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Poor sleep is assoc...
Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults.
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Sprecher, Kate E (författare)
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Koscik, Rebecca L (författare)
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Okonkwo, Ozioma C (författare)
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Sager, Mark A (författare)
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Asthana, Sanjay (författare)
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Johnson, Sterling C (författare)
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Benca, Ruth M (författare)
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Bendlin, Barbara B (författare)
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(creator_code:org_t)
- 2017
- 2017
- Engelska.
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Ingår i: Neurology. - 1526-632X. ; 89:5, s. 445-453
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- To determine the relationship between sleep quality and CSF markers of Alzheimer disease (AD) pathology in late midlife.We investigated the relationship between sleep quality and CSF AD biomarkers in a cohort enriched for parental history of sporadic AD, the Wisconsin Registry for Alzheimer's Prevention. A total of 101 participants (mean age 62.9 ± 6.2 years, 65.3% female) completed sleep assessments and CSF collection and were cognitively normal. Sleep quality was measured with the Medical Outcomes Study Sleep Scale. CSF was assayed for biomarkers of amyloid metabolism and plaques (β-amyloid 42 [Aβ42]), tau pathology (phosphorylated tau [p-tau] 181), neuronal/axonal degeneration (total tau [t-tau], neurofilament light [NFL]), neuroinflammation/astroglial activation (monocyte chemoattractant protein-1 [MCP-1], chitinase-3-like protein 1 [YKL-40]), and synaptic dysfunction/degeneration (neurogranin). To adjust for individual differences in total amyloid production, Aβ42 was expressed relative to Aβ40. To assess cumulative pathology, CSF biomarkers were expressed in ratio to Aβ42. Relationships among sleep scores and CSF biomarkers were assessed with multiple regression, controlling for age, sex, time between sleep and CSF measurements, and CSF assay batch.Worse subjective sleep quality, more sleep problems, and daytime somnolence were associated with greater AD pathology, indicated by lower CSF Aβ42/Aβ40 and higher t-tau/Aβ42, p-tau/Aβ42, MCP-1/Aβ42, and YKL-40/Aβ42. There were no significant associations between sleep and NFL or neurogranin.Self-report of poor sleep was associated with greater AD-related pathology in cognitively healthy adults at risk for AD. Effective strategies exist for improving sleep; therefore sleep health may be a tractable target for early intervention to attenuate AD pathogenesis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Amyloid beta-Peptides
- cerebrospinal fluid
- Biomarkers
- cerebrospinal fluid
- Chemokine CCL2
- cerebrospinal fluid
- Chitinase-3-Like Protein 1
- cerebrospinal fluid
- Female
- Humans
- Longitudinal Studies
- Male
- Mental Status Schedule
- Middle Aged
- Neurofilament Proteins
- cerebrospinal fluid
- Nuclear Proteins
- cerebrospinal fluid
- Peptide Fragments
- cerebrospinal fluid
- Phosphorylation
- Self Report
- Sleep
- physiology
- Sleep Wake Disorders
- cerebrospinal fluid
- psychology
- tau Proteins
- cerebrospinal fluid
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Sprecher, Kate E
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Koscik, Rebecca ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Okonkwo, Ozioma ...
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Sager, Mark A
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visa fler...
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Asthana, Sanjay
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Johnson, Sterlin ...
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Benca, Ruth M
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Bendlin, Barbara ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Neurology
- Av lärosätet
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Göteborgs universitet