Sökning: onr:"swepub:oai:gup.ub.gu.se/259620" > Ondansetron treatme...
Fältnamn | Indikatorer | Metadata |
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000 | 05011naa a2200625 4500 | |
001 | oai:gup.ub.gu.se/259620 | |
003 | SwePub | |
008 | 240910s2017 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:liu-142977 | |
009 | oai:prod.swepub.kib.ki.se:136946644 | |
024 | 7 | a https://gup.ub.gu.se/publication/2596202 URI |
024 | 7 | a https://doi.org/10.1371/journal.pone.01868242 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1429772 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1369466442 URI |
040 | a (SwePub)gud (SwePub)liud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hagbom, Marieu Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten4 aut0 (Swepub:liu)marha48 |
245 | 1 0 | a Ondansetron treatment reduces rotavirus symptoms-A randomized double-blinded placebo-controlled trial |
264 | c 2017-10-27 | |
264 | 1 | b Public Library of Science (PLoS),c 2017 |
500 | a Funding Agencies|Swedish Research Council [320301]; Swedish Research Council | |
520 | a Background Rotavirus and norovirus cause acute gastroenteritis with severe diarrhoea and vomiting, symptoms that may lead to severe dehydration and death. The objective of this randomized double-blinded placebo-controlled study was to investigate whether ondansetron, a serotonin receptor antagonist could attenuate rotavirus-and norovirus-induced vomiting and diarrhoea, which would facilitate oral rehydration and possibly accelerate recovery and reduce need for hospitalization. Children with acute gastroenteritis, aged 6 months to 16 years where enrolled (n = 104) and randomized to one single oral dose (0.15mg/kg) of ondansetron (n = 52) or placebo (n = 52). The number of diarrhoea and vomiting episodes during the 24 hours following treatment was reported as well as the number of days with symptoms. Pathogens in faeces were diagnosed by real-time PCR. Outcome parameters were analyzed for rotavirus-and noroviruspositive children. One dose of oral ondansetron reduced duration of rotavirus clinical symptoms (p = 0.014), with a median of two days. Furthermore, ondansetron reduced diarrhea episodes, most pronounced in children that had been sick for more than 3 days before treatment (p = 0.028). Ondansetron may be a beneficial treatment for children with rotavirus gastroenteritis. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
653 | a acute gastroenteritis | |
653 | a oral ondansetron | |
653 | a emergency-department | |
653 | a children | |
653 | a diarrhea | |
653 | a pathogenesis | |
653 | a serotonin | |
653 | a infection | |
653 | a dexamethasone | |
653 | a bacterial | |
653 | a Science & Technology - Other Topics | |
700 | 1 | a Novak, D.u Sahlgrens University Hospital, Sweden4 aut |
700 | 1 | a Ekstrom, M.u Sahlgrens University Hospital, Sweden4 aut |
700 | 1 | a Khalid, Y.u Sahlgrens University Hospital, Sweden4 aut |
700 | 1 | a Andersson, Mariau Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg, Sweden4 aut0 (Swepub:gu)xanman |
700 | 1 | a Lindh, Magnus,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg, Sweden4 aut0 (Swepub:gu)xlmagr |
700 | 1 | a Nordgren, Johanu Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten4 aut0 (Swepub:liu)johno12 |
700 | 1 | a Svensson, Lennartu Karolinska Institutet,Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Karolinska Institute, Sweden4 aut0 (Swepub:liu)lensv66 |
710 | 2 | a Linköpings universitetb Avdelningen för mikrobiologi och molekylär medicin4 org |
773 | 0 | t PLoS ONEd : Public Library of Science (PLoS)g 12:10q 12:10x 1932-6203 |
856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0186824&type=printable |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1156555/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/259620 |
856 | 4 8 | u https://doi.org/10.1371/journal.pone.0186824 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-142977 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:136946644 |
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