Adenosine mechanisms in the regulation of breathing in the rat.

Wessberg, Per,1954Gothenburg University,Göteborgs universitet,Farmakologiska institutionen,Department of Pharmacology (författare)

The central respiratory effects of various adenosine (A) analogues were studied in halothane-anesthetized rats. Intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of the A analogues (2-Cla, L-PIA, CHA and NECA) reduced minute ventilation (VE) due to decreases in respiratory frequency (f) as well as tidal volume (VT). Dose-dependent effects were seen after i.c.v. L-PIA in both normal and vagotomized rats. Analysis of the A-induced changes using the occluded breath technique revealed an increase in expiratory time (TE) as well as a decrease in inspiratory drive. NECA, a relatively specific A2 agonist seemed to be somewhat more potent in eliciting respiratory depression than a relatively specific A1 agonist like L-PIA. Pretreatment with the methylxanthine theophylline completely antagonized the respiratory depression induced by L-PIA. It is concluded that central A receptors are involved in the central regulation of breathing and that A interacts with the respiratory control system mainly by decreasing inspiratory neural drive and prolonging expiratory time.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
Adenosine
analogs & derivatives
pharmacology
Animals
Blood Gas Analysis
Blood Pressure
drug effects
Carbon Dioxide
pharmacology
Dose-Response Relationship
Drug
Heart Rate
drug effects
Male
Phenylisopropyladenosine
pharmacology
Rats
Rats
Inbred Strains
Receptors
Cell Surface
drug effects
Receptors
Purinergic
Respiration
drug effects
Respiratory Function Tests
Stereoisomerism
Theophylline
pharmacology
Xanthines
pharmacology

Hedner, Jan A,1953Gothenburg University,Göteborgs universitet,Farmakologiska institutionen,Department of Pharmacology(Swepub:gu)xhedja (författare)
Hedner, Thomas,1949Gothenburg University,Göteborgs universitet,Farmakologiska institutionen,Department of Pharmacology(Swepub:gu)xhedto (författare)
Persson, Bengt,1949Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine(Swepub:gu)xperbe (författare)
Jonason, JanGothenburg University,Göteborgs universitet,Farmakologiska institutionen,Department of Pharmacology (författare)
Göteborgs universitetFarmakologiska institutionen (creator_code:org_t)

Av författaren/redakt...: Wessberg, Per, 1 ...; Hedner, Jan A, 1 ...; Hedner, Thomas, ...; Persson, Bengt, ...; Jonason, Jan

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Farmakologi och ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.