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Switching the mode ...
Switching the mode of metabolism in the yeast Saccharomyces cerevisiae.
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- Otterstedt, Karin (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Larsson, Christer, 1958 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Bill, R (författare)
- Aston University
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- Ståhlberg, Anders, 1975 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Boles, E (författare)
- Johann Wolfgang Goethe Universität Frankfurt am Main,Goethe University Frankfurt
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- Hohmann, Stefan, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi, mikrobiologi,Department of Cell and Molecular Biology, Microbiology,University of Gothenburg
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- Gustafsson, Lena, 1949 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2004-05
- 2004
- Engelska.
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Ingår i: Embro reports. - : EMBO. - 1469-221X .- 1469-3178. ; 5:5, s. 532-537
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- The biochemistry of most metabolic pathways is conserved from bacteria to humans, although the control mechanisms are adapted to the needs of each cell type. Oxygen depletion commonly controls the switch from respiration to fermentation. However, Saccharomyces cerevisiae also controls that switch in response to the external glucose level. We have generated an S. cerevisiae strain in which glucose uptake is dependent on a chimeric hexose transporter mediating reduced sugar uptake. This strain shows a fully respiratory metabolism also at high glucose levels as seen for aerobic organisms, and switches to fermentation only when oxygen is lacking. These observations illustrate that manipulating a single step can alter the mode of metabolism. The novel yeast strain is an excellent tool to study the mechanisms underlying glucose-induced signal transduction.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- metabolism
- respiration
- hexose transport
- glycolysis
- signalling
- human skeletal-muscle
- individual hexose transporters
- glycolytic gene-expression
- glucose repression
- pyruvate decarboxylase
- exercise
- growth
- activation
- mechanisms
- hypoxia
- activation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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