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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03466naa a2200685 4500 | |
| 001 | oai:gup.ub.gu.se/264398 | |
| 003 | SwePub | |
| 008 | 240910s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2643982 URI |
| 024 | 7 | a https://doi.org/10.1016/j.celrep.2017.12.0672 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Lasar, D.4 aut |
| 245 | 1 0 | a Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase |
| 264 | 1 | b Elsevier BV,c 2018 |
| 520 | a Peroxisome proliferator-activated receptors (PPARs) have been suggested as the master regulators of adipose tissue formation. However, their role in regulating brown fat functionality has not been resolved. To address this question, we generated mice with inducible brown fat-specific deletions of PPAR alpha, beta/delta, and gamma, respectively. We found that both PPARa and beta/delta are dispensable for brown fat function. In contrast, we could show that ablation of PPAR gamma in vitro and in vivo led to a reduced thermogenic capacity accompanied by a loss of inducibility by beta-adrenergic signaling, as well as a shift from oxidative fatty acid metabolism to glucose utilization. We identified glycerol kinase (Gyk) as a partial mediator of PPAR gamma function and could show that Gyk expression correlates with brown fat thermogenic capacity in human brown fat biopsies. Thus, Gyk might constitute the link between PPAR gamma-mediated regulation of brown fat function and activation by b-adrenergic signaling. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
| 653 | a uncoupling protein-1 gene | |
| 653 | a ppar-gamma | |
| 653 | a adipose-tissue | |
| 653 | a insulin-resistance | |
| 653 | a white adipocytes | |
| 653 | a energy-metabolism | |
| 653 | a fat | |
| 653 | a expression | |
| 653 | a obesity | |
| 653 | a alpha | |
| 653 | a Cell Biology | |
| 653 | a akrabarty k | |
| 653 | a 1983 | |
| 653 | a journal of lipid research | |
| 653 | a v24 | |
| 653 | a p381 | |
| 700 | 1 | a Rosenwald, M.4 aut |
| 700 | 1 | a Kiehlmann, E.4 aut |
| 700 | 1 | a Balaz, M.4 aut |
| 700 | 1 | a Tall, B.4 aut |
| 700 | 1 | a Opitz, L.4 aut |
| 700 | 1 | a Lidell, Martin,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine4 aut0 (Swepub:gu)xlidma |
| 700 | 1 | a Zamboni, N.4 aut |
| 700 | 1 | a Krznar, P.4 aut |
| 700 | 1 | a Sun, W. F.4 aut |
| 700 | 1 | a Varga, L.4 aut |
| 700 | 1 | a Stefanicka, P.4 aut |
| 700 | 1 | a Ukropec, J.4 aut |
| 700 | 1 | a Nuutila, P.4 aut |
| 700 | 1 | a Virtanen, K.4 aut |
| 700 | 1 | a Amri, E. Z.4 aut |
| 700 | 1 | a Enerbäck, Sven,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine4 aut0 (Swepub:gu)xenesv |
| 700 | 1 | a Wahli, W.4 aut |
| 700 | 1 | a Wolfrum, C.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för biomedicin4 org |
| 773 | 0 | t Cell Reportsd : Elsevier BVg 22:3, s. 760-773q 22:3<760-773x 2211-1247 |
| 856 | 4 | u http://www.cell.com/article/S2211124717319046/pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/264398 |
| 856 | 4 8 | u https://doi.org/10.1016/j.celrep.2017.12.067 |
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