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Manganese inhibits ...
Manganese inhibits viability of prostate cancer cells
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- Hernroth, Bodil (författare)
- Man and Biosphere Health (MABH),Royal Swedish Academy of Sciences
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- Holm, I. (författare)
- Man and Biosphere Health (MABH)
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- Gondikas, Andreas P., 1981 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för marina vetenskaper,Department of marine sciences,University of Gothenburg
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- Tassidis, H. (författare)
- Man and Biosphere Health (MABH)
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(creator_code:org_t)
- 2018-01-02
- 2018
- Engelska.
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Ingår i: Anticancer Research. - : Anticancer Research USA Inc.. - 0250-7005 .- 1791-7530. ; 38:1, s. 137-145
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https://gup.ub.gu.se...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Background/Aim: Androgen deprivation therapy is usually in the initial phase a successful treatment for prostate cancer but eventually most patients develop androgen-independent metastatic disease. This study investigated if manganese (Mn) reduces viability of prostate cancer via induction of apoptosis. Materials and Methods: The prostate cancer cell lines PC3, DU145 and LNCaP underwent dose- and time-dependent screening of viability, analyzed by the 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay. Flow cytometry was used for the cell-cycle and apoptosis analyses. Intracellular Mn concentration was measured using inductively coupled plasma-mass spectrometry. Results: At Mn concentrations of 200-1000 µM, the effect on viability was most pronounced in PC3 followed by LNCaP cells. These cell lines also showed higher intracellular concentration of Mn compared to DU145. In all cell lines, Mn increased the proportion of cells arrested in the G0/G1 phase and induced apoptosis. Conclusion: To our knowledge, this is the first report demonstrating Mn as a potential agent in prostate cancer therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Apoptosis
- Cell viability
- DU145
- LNCaP
- Manganese
- PC3
- Prostate cancer
- antineoplastic agent
- cell cycle
- cell survival
- drug effects
- human
- male
- prostate tumor
- tumor cell line
- Antineoplastic Agents
- Cell Line
- Tumor
- Humans
- Prostatic Neoplasms
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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