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Embolic strokes of ...
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Martinez-Majander, N.
(författare)
Embolic strokes of undetermined source in young adults: baseline characteristics and long-term outcome
- Artikel/kapitelEngelska2018
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LIBRIS-ID:oai:gup.ub.gu.se/265620
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https://gup.ub.gu.se/publication/265620URI
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https://doi.org/10.1111/ene.13540DOI
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Ämneskategori:art swepub-publicationtype
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Background and purposeEmbolic strokes of undetermined source (ESUS) are a recent entity, not yet thoroughly investigated in young stroke patients. The clinical characteristics and long-term risks of vascular events and all-cause mortality between young-onset ESUS and other aetiological subgroups were compared. MethodsPatients with ESUS were identified amongst the 1008 patients aged 15-49 years with first-ever ischaemic stroke in Helsinki Young Stroke Registry, and primary end-points were defined as recurrent stroke, composite vascular events and all-cause mortality. Cumulative 15-year risks for each end-point were analysed with life tables and adjusted risks were based on Cox proportional hazard analyses. ResultsOf the 971 eligible patients, 203 (20.9%) were classified as ESUS. They were younger (median age 40 years, interquartile range 32-46 vs. 45 years, 39-47), more often female (43.3% vs. 35.7%) and had fewer cardiovascular risk factors than other modified TOAST groups. With a median follow-up time of 10.1 years, ESUS patients had the second lowest cumulative risk of recurrent stroke and composite vascular events and lowest mortality compared to other TOAST groups. Large-artery atherosclerosis and small vessel disease carried significantly higher risk for recurrent stroke than did ESUS, whilst no difference appeared between cardioembolism from high-risk sources and ESUS. ConclusionsIn our cohort, ESUS patients were younger and had milder cardiovascular risk factor burden and generally better long-term outcome compared to other causes of young-onset stroke. The comparable risk of recurrent stroke between ESUS and high-risk sources of cardioembolism might suggest similarities in their pathophysiology.
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Aarnio, K.
(författare)
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Pirinen, J.
(författare)
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Lumikari, T.
(författare)
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Nieminen, T.
(författare)
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Lehto, M.
(författare)
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Sinisalo, J.
(författare)
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Kaste, M.
(författare)
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Tatlisumak, TurgutGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xtatlt
(författare)
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Putaala, J.
(författare)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Neurology: Wiley25:3, s. 535-5411351-51011468-1331
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