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Digoxin use and low...
Digoxin use and lower risk of 30-day all-cause readmission in older patients with heart failure and reduced ejection fraction receiving β-blockers
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Lam, P. H. (författare)
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Bhyan, P. (författare)
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Arundel, C. (författare)
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Dooley, D. J. (författare)
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Sheriff, H. M. (författare)
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Mohammed, S. F. (författare)
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Fonarow, G. C. (författare)
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Morgan, C. J. (författare)
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Aronow, W. S. (författare)
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Allman, R. M. (författare)
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- Waagstein, Finn, 1938 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Ahmed, A. (författare)
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(creator_code:org_t)
- 2018-03-22
- 2018
- Engelska.
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Ingår i: Clinical Cardiology. - : Wiley. - 0160-9289. ; 41:3, s. 406-412
- Relaterad länk:
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https://onlinelibrar...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Digoxin use has been associated with a lower risk of 30-day all-cause admission and readmission in patients with heart failure and reduced ejection fraction (HFrEF). Hypothesis: Digoxin use will be associated with improved outcomes in patients with HFrEF receiving β-blockers. Methods: Of the 3076 hospitalized Medicare beneficiaries with HFrEF (EF <45%), 1046 received a discharge prescription for β-blockers, of which 634 were not on digoxin. Of the 634, 204 received a new discharge prescription for digoxin. Propensity scores for digoxin use, estimated for each of the 634 patients, were used to assemble a matched cohort of 167 pairs of patients receiving and not receiving digoxin, balanced on 30 baseline characteristics. Matched patients (n = 334) had a mean age of 74 years and were 46% female and 30% African American. Results: 30-day all-cause readmission occurred in 15% and 27% of those receiving and not receiving digoxin, respectively (hazard ratio [HR]: 0.51, 95% confidence interval [CI]: 0.31-0.83, P = 0.007). This beneficial association persisted during 4 years of follow-up (HR: 0.72, 95% CI: 0.57-0.92, P = 0.008). Digoxin use was also associated with a lower risk of the combined endpoint of all-cause readmission or all-cause mortality at 30 days (HR: 0.54, 95% CI: 0.34-0.86, P = 0.009) and at 4 years (HR: 0.76, 95% CI: 0.61-0.96, P = 0.020). Conclusions: In hospitalized patients with HFrEF receiving β-blockers, digoxin use was associated with a lower risk of 30-day all-cause readmission but not mortality, which persisted during longer follow-up. © 2018 Wiley Periodicals, Inc.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Digoxin
- Heart Failure
- Hospital Readmission
- β-Blockers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lam, P. H.
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Bhyan, P.
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Arundel, C.
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Dooley, D. J.
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Sheriff, H. M.
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Mohammed, S. F.
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visa fler...
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Fonarow, G. C.
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Morgan, C. J.
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Aronow, W. S.
-
Allman, R. M.
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Waagstein, Finn, ...
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Ahmed, A.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Clinical Cardiol ...
- Av lärosätet
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Göteborgs universitet