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A Randomized Clinic...
A Randomized Clinical Trial of the Effect of Continuous Glucose Monitoring on Nocturnal Hypoglycemia, Daytime Hypoglycemia, Glycemic Variability, and Hypoglycemia Confidence in Persons with Type 1 Diabetes Treated with Multiple Daily Insulin Injections (GOLD-3)
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- Olafsdottir, Arndis, 1978 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,NU Hosp Grp, Dept Med, Trollhattan Uddevalla, Sweden.;Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.
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- Polonsky, W. (författare)
- Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
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- Bolinder, J. (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Hirsch, I. B. (författare)
- Univ Washington, Sch Med, Seattle, WA USA.
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- Wedel, Hans (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för hälsometri,Institute of Medicine, Department of Public Health and Community Medicine, Health Metrics,Univ Gothenburg, Hlth Metr Sahlgrenska Acad, Gothenburg, Sweden.
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- Nystrom, T. (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Wijkman, Magnus (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Medicinkliniken ViN
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- Schwarcz, E. (författare)
- Orebro Univ, Fac Med & Hlth, Dept Internal Med, Orebro, Sweden.
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- Hellman, Jarl (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism,Uppsala Univ, Sweden
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- Heise, T. (författare)
- Profil, Neuss, Germany.
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- Lind, Marcus, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,NU Hosp Grp, Dept Med, Trollhattan Uddevalla, Sweden.;Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.
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- Dahlqvist, Sofia (författare)
- NU Hosp Grp, Dept Med, Trollhattan Uddevalla, Sweden.
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(creator_code:org_t)
- Mary Ann Liebert Inc, 2018
- 2018
- Engelska.
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Ingår i: Diabetes Technology & Therapeutics. - : Mary Ann Liebert Inc. - 1520-9156 .- 1557-8593. ; 20:4, s. 274-284
- Relaterad länk:
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https://www.liebertp...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: To evaluate the effects of continuous glucose monitoring (CGM) on nocturnal and daytime hypoglycemia in persons with type 1 diabetes treated with multiple daily insulin injections (MDI); we also evaluated factors related to differences in hypoglycemia confidence in this population. Methods: Evaluations were performed from the GOLD randomized trial, an open-label multicenter crossover randomized clinical trial (n=161) over 69 weeks comparing CGM to self-measurement of blood glucose (SMBG) in persons with type 1 diabetes treated with MDI. Masked CGM and the hypoglycemia confidence questionnaire were used for evaluations. Results: Time with nocturnal hypoglycemia, glucose levels <70mg/dL was reduced by 48% (10.2 vs. 19.6min each night, P<0.001) and glucose levels <54mg/dL by 65%. (3.1 vs. 8.9min, P<0.001). For the corresponding glucose cutoffs, daytime hypoglycemia was reduced by 40% (29 vs. 49min, P<0.001) and 54% (8 vs. 18min., P<0.001), respectively. Compared with SMBG, CGM use improved hypoglycemia-related confidence in social situations (P=0.016) and confidence in more broadly avoiding serious problems due to hypoglycemia (P=0.0020). Persons also reported greater confidence in detecting and responding to decreasing blood glucose levels (thereby avoiding hypoglycemia) during CGM use (P=0.0033) and indicated greater conviction that they could more freely live their lives despite the risk of hypoglycemia (P=0.022). Conclusion: CGM reduced time in both nocturnal and daytime hypoglycemia in persons with type 1 diabetes treated with MDI and improved hypoglycemia-related confidence, especially in social situations, thus contributing to greater well-being and quality of life. Trial registration: ClinicalTrials.gov, number NCT02092051.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Type 1 diabetes mellitus
- Continuous glucose monitoring
- Randomized clinical trial
- Hypoglycemia
- blood-glucose
- impaired awareness
- pump therapy
- hypocompass
- frequency
- accuracy
- adults
- Endocrinology & Metabolism
- Type 1 diabetes mellitus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Olafsdottir, Arn ...
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Polonsky, W.
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Bolinder, J.
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Hirsch, I. B.
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Wedel, Hans
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Nystrom, T.
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visa fler...
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Wijkman, Magnus
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Schwarcz, E.
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Hellman, Jarl
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Heise, T.
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Lind, Marcus, 19 ...
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Dahlqvist, Sofia
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetes Technol ...
- Av lärosätet
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Göteborgs universitet
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Uppsala universitet
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Karolinska Institutet
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Linköpings universitet