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Low levels of anti-...
Low levels of anti-secretory factor in placenta are associated with preterm birth and inflammation
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- Gustafsson, A. M. (författare)
- Karolinska Institutet
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- Fransson, Emma, PhD, 1973- (författare)
- Karolinska Institutet
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Dubicke, A. (författare)
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Hjelmstedt, A. K. (författare)
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Ekman-Ordeberg, G. (författare)
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- Silfverdal, Sven-Arne (författare)
- Umeå universitet,Pediatrik
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- Lange, Stefan, 1948 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Jennische, Eva, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Bohlin, K. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2018-01-08
- 2018
- Engelska.
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Ingår i: Acta Obstetricia Et Gynecologica Scandinavica. - : Wiley. - 0001-6349 .- 1600-0412. ; 97:3, s. 349-356
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Abstract
Ämnesord
Stäng
- IntroductionAnti-secretory factor is a protein that regulates secretory and inflammatory processes and preterm birth is associated with inflammation. Therefore, our hypothesis was that anti-secretory factor might play a role in immune reactivity and homeostasis during pregnancy. Material and methodsFollowing spontaneous onset of labor and preterm or term delivery, placenta biopsies were collected. The levels of anti-secretory factor and markers of inflammation (CD68, CD163) and vascularization (CD34, smooth muscle actin) were analyzed by immunohistochemistry. ResultsThe 61 placental biopsies included 31 preterm (<37 weeks of gestation) and 30 term (37-41 weeks) samples. The preterm placentas exhibited lower levels of anti-secretory factor (p = 0.008) and larger numbers of CD68-positive cells (p < 0.001) compared to term. Preterm placentas had blood vessel of smaller diameter (p = 0.036) indicative of immaturity. The level of interleukin-6 in cord blood was higher after very preterm than term birth, suggesting a fetal inflammatory response. The placenta level of anti-secretory factor was positively correlated to the length of gestation (p = 0.025) and negatively correlated to the levels of the inflammatory markers CD68 (p = 0.015) and CD163 (p = 0.028). ConclusionsPreterm delivery is associated with low levels of anti-secretory factor in placenta. Inflammation, a potential trigger of preterm birth, is more pronounced in the preterm placenta and inversely related to the placental level of anti-secretory factor, suggesting both a link and a potential target for intervention.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Anti-secretory factor
- preterm birth
- placenta
- inflammation
- vascularization
- antisecretory factor
- clinical-significance
- hofbauer cells
- chorioamnionitis
- macrophages
- pregnancy
- epidemiology
- definition
- markers
- plasma
- Obstetrics & Gynecology
- Anti-secretory factor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Gustafsson, A. M ...
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Fransson, Emma, ...
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Dubicke, A.
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Hjelmstedt, A. K ...
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Ekman-Ordeberg, ...
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Silfverdal, Sven ...
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Lange, Stefan, 1 ...
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Jennische, Eva, ...
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Bohlin, K.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reproduktionsmed ...
- Artiklar i publikationen
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Acta Obstetricia ...
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Uppsala universitet
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Karolinska Institutet