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Design and Biologic...
Design and Biological Evaluation of Antifouling Dihydrostilbene Oxime Hybrids
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- Moodie, Lindon W. K. (författare)
- Umeå universitet,Kemiska institutionen,Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway,UiT The Arctic University of Norway, Norway; Umeå University, Sweden
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- Cervin, Gunnar, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för marina vetenskaper,Department of marine sciences,University of Gothenburg, Sweden
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- Trepos, R. (författare)
- Université de Bretagne Occidentale, France
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- Labriere, C. (författare)
- UiT The Arctic University of Norway, Norway
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- Hellio, C. (författare)
- Université de Bretagne Occidentale, France
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- Pavia, Henrik, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för marina vetenskaper,Department of marine sciences,University of Gothenburg, Sweden
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- Svenson, Johan (författare)
- RISE,Kemi och material,UiT The Arctic University of Norway, Norway
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(creator_code:org_t)
- 2018-03-13
- 2018
- Engelska.
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Ingår i: Marine Biotechnology. - : Springer Science and Business Media LLC. - 1436-2228 .- 1436-2236. ; 20:2, s. 257-267
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- By combining the recently reported repelling natural dihydrostilbene scaffold with an oxime moiety found in many marine antifoulants, a library of nine antifouling hybrid compounds was developed and biologically evaluated. The prepared compounds were shown to display a low antifouling effect against marine bacteria but a high potency against the attachment and growth of microalgae down to MIC values of 0.01 mu g/mL for the most potent hybrid. The mode of action can be characterized as repelling via a reversible non-toxic biostatic mechanism. Barnacle cyprid larval settlement was also inhibited at low mu g/mL concentrations with low levels or no toxicity observed. Several of the prepared compounds performed better than many reported antifouling marine natural products. While several of the prepared compounds are highly active as antifoulants, no apparent synergy is observed by incorporating the oxime functionality into the dihydrostilbene scaffold. This observation is discussed in light of recently reported literature data on related marine natural antifoulants and antifouling hybrids as a potentially general strategy for generation of improved antifoulants.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Oceanografi, hydrologi och vattenresurser (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Oceanography, Hydrology and Water Resources (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Miljöbioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Environmental Biotechnology (hsv//eng)
Nyckelord
- Antifouling
- Dihydrostilbene
- Batatasin
- Oxime
- Ianthelline
- Hybrid
- helicobacter-pylori urease
- synthetic analogs
- natural-products
- marine
- sponges
- inhibitors
- potent
- surfaces
- metabolites
- derivatives
- agents
- Biotechnology & Applied Microbiology
- Marine & Freshwater Biology
- Antifouling
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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