Sökning: onr:"swepub:oai:gup.ub.gu.se/268678" >
Is long-term heavy ...
Is long-term heavy alcohol consumption toxic for brain serotonergic neurons? Relationship between years of excessive alcohol consumption and serotonergic neurotransmission.
-
Berggren, Ulf (författare)
-
Eriksson, Matts (författare)
-
- Fahlke, Claudia, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
-
visa fler...
-
Balldin, Jan (författare)
-
visa färre...
-
(creator_code:org_t)
- 2002
- 2002
- Engelska.
-
Ingår i: Drug and alcohol dependence. - 0376-8716. ; 65:2, s. 159-65
- Relaterad länk:
-
https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- The relationship between years of excessive alcohol consumption and central serotonergic neurotransmission, as assessed by the prolactin (PRL) response to D-fenfluramine, was investigated in 22 male alcohol-dependent subjects. A negative correlation was obtained, that is, the longer duration of excessive alcohol consumption the lower PRL response to D-fenfluramine. It is therefore suggested that long duration of excessive alcohol consumption in alcohol-dependent subjects causes a reduction in central serotonergic neurotransmission, possibly by a toxic effect of alcohol on serotonin neurons. The relationship between depressive and anxiety symptoms during on-going drinking and the PRL response to D-fenfluramine was also investigated. No such correlations were obtained, suggesting that reduction in central serotonergic neurotransmission does not pre-dispose to the development of depressive and anxiety symptoms, at least in relation to on-going drinking in alcohol-dependent subjects.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- Alcoholism
- diagnosis
- metabolism
- Brain
- drug effects
- metabolism
- Ethanol
- adverse effects
- pharmacokinetics
- Fenfluramine
- pharmacokinetics
- Humans
- Male
- Middle Aged
- Receptors
- Serotonin
- drug effects
- metabolism
- Serotonin
- Serotonin Uptake Inhibitors
- pharmacokinetics
- Severity of Illness Index
- Synaptic Transmission
- drug effects
- Time Factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas