Sökning: onr:"swepub:oai:gup.ub.gu.se/268808" >
Biochemical and beh...
Biochemical and behavioral evidence for an interaction between ethanol and calcium channel antagonists.
-
Engel, J A (författare)
-
- Fahlke, Claudia, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
-
Hulthe, P (författare)
-
visa fler...
-
Hård, E (författare)
-
Johannessen, K (författare)
-
Snape, B (författare)
-
Svensson, L (författare)
-
visa färre...
-
(creator_code:org_t)
- 1988
- 1988
- Engelska.
-
Ingår i: Journal of neural transmission. ; 74:3, s. 181-93
- Relaterad länk:
-
https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- In the present series of experiments we have studied the effects of the dihydropyridine calcium channel antagonist nifedipine on ethanol-induced changes in behavior and dopamine (DA) release and metabolism. The locomotor-stimulatory effect of low doses of ethanol (2.5 g/kg) was antagonized by nifedipine, whereas ethanol-induced sedation observed after higher doses (4.5 g/kg) was potentiated. Biochemical studies indicated that ethanol enhanced the metabolism and release of DA in the striatum and the DA-rich limbic regions measured by post mortem analyses of DA-metabolites by HPLC with electrochemical detection and by in vivo voltammetry in anaesthetized rats, respectively. Pretreatment with nifedipine antagonized the stimulatory effects of ethanol on the DA-system. Nifedipine reduced the preference for ethanol, estimated by the relative intake of ethanol (6% v/v) and water in a free-choice situation, suggesting an influence of nifedipine not only on the stimulatory but also on the positive reinforcing effects of ethanol. The present results suggest that the locomotor-stimulatory and positive reinforcing effects of ethanol as well as its enhancing effect on dopaminergic activity may involve an enhancement of calcium mediated mechanisms.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- Animals
- Calcium Channel Blockers
- pharmacology
- Dopamine
- metabolism
- Dose-Response Relationship
- Drug
- Drug Interactions
- Ethanol
- pharmacology
- Female
- Male
- Mice
- Motor Activity
- drug effects
- Nifedipine
- pharmacology
- Rats
- Rats
- Inbred Strains
- Time Factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas