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The neutrophil-mobi...
The neutrophil-mobilizing cytokine interleukin-26 in the airways of long-term tobacco smokers
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Che, K. F. (författare)
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Tufvesson, E. (författare)
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- Tengvall, Sara, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Lappi-Blanco, E. (författare)
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Kaarteenaho, R. (författare)
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Levanen, B. (författare)
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Ekberg, M. (författare)
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Brauner, A. (författare)
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Wheelock, A. M. (författare)
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Bjermer, L. (författare)
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Skold, C. M. (författare)
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Linden, A. (författare)
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(creator_code:org_t)
- 2018-05-21
- 2018
- Engelska.
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Ingår i: Clinical Science. - : Portland Press Ltd.. - 0143-5221 .- 1470-8736. ; 132:9, s. 959-983
- Relaterad länk:
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https://portlandpres...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Long-term tobacco smokers with chronic obstructive pulmonary disease (COPD) or chronic bronchitis display an excessive accumulation of neutrophils in the airways; an inflammation that responds poorly to established therapy. Thus, there is a need to identify new molecular targets for the development of effective therapy. Here, we hypothesized that the neutrophil-mobilizing cytokine interleukin (IL)-26 (IL-26) is involved in airway inflammation amongst long-term tobacco smokers with or without COPD, chronic bronchitis or colonization by pathogenic bacteria. By analyzing bronchoalveolar lavage (BAL), bronchail wash (BW) and induced sputum (IS) samples, we found increased extracellular IL-26 protein in the airways of long-term smokers in vivo without further increase amongst those with clinically stable COPD. In human alveolar macrophages (AM) in vitro, the exposure to water-soluble tobacco smoke components (WTC) enhanced IL-26 gene and protein. In this cell model, the same exposure increased gene expression of the IL-26 receptor complex (IL10R2 and IL20R1) and nuclear factor kappa B (NF-kappa B); a proven regulator of IL-26 production. In the same cell model, recombinant human IL-26 in vitro caused a concentration-dependent increase in the gene expression of NF-kappa B and several pro-inflammatory cytokines. In the long-term smokers, we also observed that extracellular IL-26 protein in BAL samples correlates with measures of lung function, tobacco load, and several markers of neutrophil accumulation. Extracellular IL-26 was further increased in long-term smokers with exacerbations of COPD (IS samples), with chronic bronchitis (BAL samples) or with colonization by pathogenic bacteria (IS and BW samples). Thus, IL-26 in the airways emerges as a promising target for improving the understanding of the pathogenic mechanisms behind several pulmonary morbidities in long-term tobacco smokers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- obstructive pulmonary-disease
- chronic-bronchitis
- bronchoalveolar
- lavage
- epithelial-cells
- copd
- exacerbations
- infection
- inflammation
- mediators
- asthma
- Research & Experimental Medicine
- ger i
- 1975
- new england journal of medicine
- v292
- p563
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Che, K. F.
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Tufvesson, E.
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Tengvall, Sara, ...
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Lappi-Blanco, E.
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Kaarteenaho, R.
-
Levanen, B.
-
visa fler...
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Ekberg, M.
-
Brauner, A.
-
Wheelock, A. M.
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Bjermer, L.
-
Skold, C. M.
-
Linden, A.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
- Artiklar i publikationen
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Clinical Science
- Av lärosätet
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Göteborgs universitet