Sökning: onr:"swepub:oai:gup.ub.gu.se/271519" > Non-alcoholic fatty...
Fältnamn | Indikatorer | Metadata |
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000 | 07504naa a2200685 4500 | |
001 | oai:gup.ub.gu.se/271519 | |
003 | SwePub | |
008 | 240910s2018 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-364359 | |
009 | oai:lup.lub.lu.se:70fb2139-3cf1-4e79-8207-bc6f7045343f | |
024 | 7 | a https://gup.ub.gu.se/publication/2715192 URI |
024 | 7 | a https://doi.org/10.1371/journal.pone.02026662 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3643592 URI |
024 | 7 | a https://lup.lub.lu.se/record/70fb2139-3cf1-4e79-8207-bc6f7045343f2 URI |
040 | a (SwePub)gud (SwePub)uud (SwePub)lu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gummesson, Anders,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska Academy,Sahlgrenska University Hospital4 aut0 (Swepub:gu)xguman |
245 | 1 0 | a Non-alcoholic fatty liver disease is a strong predictor of coronary artery calcification in metabolically healthy subjects: A cross-sectional, population-based study in middle-aged subjects |
264 | c 2018-08-22 | |
264 | 1 | b Public Library of Science (PLoS),c 2018 |
520 | a Objectives This study aims to estimate the relationship between non-alcoholic fatty liver disease (NAFLD) and measures of atherosclerotic cardiovascular disease (ASCVD), and to determine to what extent such relationships are modified by metabolic risk factors. The study was conducted in the population-based Swedish CArdioPulmonary bioImage Study (SCAPIS) pilot cohort (n = 1015, age 50-64 years, 51.2% women). NAFLD was defined as computed tomography liver attenuation <= 40 Hounsfield Units, excluding other causes of liver fat. Coronary artery calcification score (CACS) was assessed using the Agatston method. Carotid plaques and intima media thickness (IMT) were measured by ultrasound. Metabolic status was based on assessments of glucose homeostasis, serum lipids, blood pressure and inflammation. A propensity score model was used to balance NAFLD and non NAFLD groups with regards to potential confounders and associations between NAFLD status and ASCVD variables in relation to metabolic status were examined by logistic and generalized linear regression models. NAFLD was present in 106 (10.4%) of the subjects and strongly associated with obesity-related traits. NAFLD was significantly associated with CACS after adjustment for confounders and metabolic risk factors (OR 1.77, 95% CI 1.07-2.94), but not with carotid plaques and IMT. The strongest association between NAFLD and CACS was observed in subjects with few metabolic risk factors (n = 612 [60% of all] subjects with 0-1 out of 7 predefined metabolic risk factors; OR 5.94, 95% CI 2.13-16.6). NAFLD was independently associated with coronary artery calcification but not with measures of carotid atherosclerosis in this cohort. The association between NAFLD and CACS was most prominent in the metabolically healthy subjects. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a intima-media thickness | |
653 | a type-2 diabetic-patients | |
653 | a cardiovascular-disease | |
653 | a hepatic steatosis | |
653 | a subclinical atherosclerosis | |
653 | a carotid atherosclerosis | |
653 | a computed-tomography | |
653 | a association | |
653 | a calcium | |
653 | a ct | |
653 | a Science & Technology - Other Topics | |
700 | 1 | a Strömberg, Ulf,d 1964u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för hälsometri,Institute of Medicine, Department of Public Health and Community Medicine, Health Metrics,Sahlgrenska Academy4 aut0 (Swepub:gu)xstrou |
700 | 1 | a Schmidt, Caroline,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska Academy4 aut0 (Swepub:gu)xschca |
700 | 1 | a Kullberg, Joel,d 1979-u Uppsala University,Uppsala universitet,Radiologi4 aut0 (Swepub:uu)jokul377 |
700 | 1 | a Angerås, Oskar,d 1976u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital,Sahlgrenska Academy4 aut0 (Swepub:gu)xangos |
700 | 1 | a Lindgren, Stefanu Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-sli |
700 | 1 | a Hjelmgren, Olau Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska Academy,Sahlgrenska University Hospital4 aut0 (Swepub:gu)xhjelo |
700 | 1 | a Torén, Kjell,d 1952u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Sahlgrenska Academy4 aut0 (Swepub:gu)xtorkj |
700 | 1 | a Rosengren, Annika,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska Academy4 aut0 (Swepub:gu)xrosan |
700 | 1 | a Fagerberg, Björn,d 1943u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska Academy4 aut0 (Swepub:gu)xfagbj |
700 | 1 | a Brandberg, J.u Sahlgrenska University Hospital4 aut |
700 | 1 | a Bergström, Göran,d 1964u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital,Sahlgrenska Academy4 aut0 (Swepub:gu)xbgort |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org |
773 | 0 | t Plos Oned : Public Library of Science (PLoS)g 13:8q 13:8x 1932-6203 |
856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0202666&type=printable |
856 | 4 | u https://doi.org/10.1371/journal.pone.0202666y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1258744/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://dx.doi.org/10.1371/journal.pone.0202666x freey FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/271519 |
856 | 4 8 | u https://doi.org/10.1371/journal.pone.0202666 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-364359 |
856 | 4 8 | u https://lup.lub.lu.se/record/70fb2139-3cf1-4e79-8207-bc6f7045343f |
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