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How is cardiac trop...
How is cardiac troponin released from injured myocardium?
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- Mair, J. (författare)
- Med Univ Innsbruck, Heart Ctr, Dept Internal Med Cardiol & Angiol 3, Innsbruck, Austria
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- Lindahl, Bertil, 1957- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Hammarsten, Ola (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Univ Gothenburg, Dept Clin Chem & Transfus Med, Gothenburg, Sweden
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- Muller, C. (författare)
- Univ Hosp Basel, Dept Cardiol, Basel, Switzerland; Univ Hosp Basel, Cardiovasc Res Inst Basel, Basel, Switzerland
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- Giannitsis, E. (författare)
- Heidelberg Univ, Med Klin 3, Dept Cardiol, Heidelberg, Germany
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- Huber, K. (författare)
- Wilhelminen Hosp, Dept Med Cardiol & Intens Care Med, Vienna, Austria; Sigmund Freud Univ, Med Sch, Vienna, Austria
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- Mockel, M. (författare)
- Charite Univ Med Berlin, Div Emergency Med, Berlin, Germany; Charite Univ Med Berlin, Dept Cardiol, Berlin, Germany
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- Plebani, M. (författare)
- Univ Hosp Padova, Dept Lab Med, Padua, Italy
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- Thygesen, K. (författare)
- Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark
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- Jaffe, A. S. (författare)
- Mayo Clin, Rochester, MN USA; Med Sch, Rochester, MN USA
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Acute Cardiovasc Care Assoc, Acca (författare)
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(creator_code:org_t)
- 2017-12-27
- 2018
- Engelska.
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Ingår i: European Heart Journal-Acute Cardiovascular Care. - : Oxford University Press (OUP). - 2048-8726 .- 2048-8734. ; 7:6, s. 553-560
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https://journals.sag...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Cardiac troponin I and cardiac troponin T are nowadays the criterion biomarkers for the laboratory diagnosis of acute myocardial infarction due to their very high sensitivities and specificities for myocardial injury. However, still many aspects of their degradation, tissue release and elimination from the human circulation are incompletely understood. Myocardial injury may be caused by a variety of different mechanisms, for example, myocardial ischaemia, inflammatory and immunological processes, trauma, drugs and toxins, and myocardial necrosis is preceded by a substantial reversible prelethal phase. Recent experimental data in a pig model of myocardial ischaemia demonstrated cardiac troponin release into the circulation from apoptotic cardiomyocytes as an alternative explanation for clinical situations with increased cardiac troponin without any other evidence for myocardial necrosis. However, the comparably lower sensitivities of all currently available imaging modalities, including cardiac magnetic resonance imaging for the detection of particularly non-focal myocardial necrosis in patients, has to be considered for cardiac troponin test result interpretation in clinical settings without any other evidence for myocardial necrosis apart from increased cardiac troponin concentrations as well.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Cardiac troponin I
- cardiac troponin T
- myocardial injury
- release
- reversible
- necrosis
- apoptosis
- irreversible cell-damage
- membrane repair
- ischemia
- permeability
- heart
- rat
- classification
- regeneration
- definition
- predictors
- Cardiac troponin I
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Mair, J.
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Lindahl, Bertil, ...
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Hammarsten, Ola
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Muller, C.
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Giannitsis, E.
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Huber, K.
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visa fler...
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Mockel, M.
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Plebani, M.
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Thygesen, K.
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Jaffe, A. S.
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Acute Cardiovasc ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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European Heart J ...
- Av lärosätet
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Göteborgs universitet
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Uppsala universitet