• The aim of this study was to determine the role of change in body mass index (BMI) during puberty, independent of childhood overweight, for the risk of adult type 2 diabetes in men.We included 36,176 men who had weight and height measured at age 8 (childhood) and 20 (young adult age) available from the BMI Epidemiology Study (BEST) and the Conscription register. Information on type 2 diabetes (n=1,777) was retrieved from the Swedish National Patient Register. Hazard ratios and 95% Confidence Intervals were estimated by Cox regressions including birth year and country of birth as covariates. Because the assumption of proportional hazards was violated for the association between BMI change during puberty and type 2 diabetes, we split the follow-up time into early (≤55.7 years) and late (>55.7 years).Both childhood overweight and a high BMI increase during puberty associated with risk of adult type 2 diabetes. Men with childhood overweight that normalized during puberty did not have a significantly increased risk of type 2 diabetes (Early type 2 diabetes 1.28[0.89; 1.82]; Late type 2 diabetes 1.35[0.97; 1.87]). Men who developed overweight during puberty (Early 4.67[3.90; 5.58]; Late 2.85[2.25; 3.61]) and men overweight at both childhood and young adult age (Early 4.82[3.84; 6.05]; Late 3.04[2.27; 4.06]) had substantially increased risk of type 2 diabetes compared with men who were never overweight.BMI change during puberty is an important, and childhood BMI a modest, independent determinant of adult type 2 diabetes risk in men.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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