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Identification of P...
Identification of Potential Plasma Biomarkers for Abdominal Aortic Aneurysm Using Tandem Mass Tag Quantitative Proteomics
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- Henriksson, Anders E. (författare)
- Mittuniversitetet,Avdelningen för naturvetenskap,Sundsvall County Hospital, Sundsvall
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- Lindqvist, M. (författare)
- Sundsvall County Hospital, Sundsvall
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- Sihlbom, Carina, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Core Facilities, Proteomics,Core Facilities, Proteomics,University of Gothenburg, Gothenburg
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- Bergstrom, J. (författare)
- University of Gothenburg, Gothenburg
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- Bylund, Dan, 1969- (författare)
- Mittuniversitetet,Avdelningen för naturvetenskap
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(creator_code:org_t)
- 2018-10-18
- 2018
- Engelska.
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Ingår i: Proteomes. - : MDPI AG. - 2227-7382. ; 6:4
- Relaterad länk:
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https://www.mdpi.com...
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https://doi.org/10.3...
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https://miun.diva-po... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Plasma biomarkers that identify abdominal aortic aneurysm (AAA) rupture risk would greatly assist in stratifying patients with small aneurysms. Identification of such biomarkers has hitherto been unsuccessful over a range of studies using different methods. The present study used an alternative proteomic approach to find new, potential plasma AAA biomarker candidates. Pre-fractionated plasma samples from twelve patients with AAA and eight matched controls without aneurysm were analyzed by mass spectrometry applying a tandem mass tag (TMT) technique. Eight proteins were differentially regulated in patients compared to controls, including decreased levels of the enzyme bleomycin hydrolase. The down-regulation of this enzyme was confirmed in an extended validation study using an enzyme-linked immunosorbent assay (ELISA). The TMT-based proteomic approach thus identified novel potential plasma biomarkers for AAA.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- aortic aneurysm
- biomarker
- bleomycin hydrolase
- clinical proteomics
- mass spectrometry
- proteomics
- circulating biomarkers
- homocysteine
- mechanisms
- markers
- serum
- Biochemistry & Molecular Biology
- Aortic aneurysm
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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