onr:"swepub:oai:gup.ub.gu.se/279810"
Sökning: onr:"swepub:oai:gup.ub.gu.se/279810" > Inhibition of Meval...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04092naa a2200781 4500 | |
| 001 | oai:gup.ub.gu.se/279810 | |
| 003 | SwePub | |
| 008 | 240528s2019 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:140608782 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2798102 URI |
| 024 | 7 | a https://doi.org/10.1016/j.cmet.2018.11.0172 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1406087822 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Balaz, M.4 aut |
| 245 | 1 0 | a Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation |
| 264 | 1 | b Elsevier BV,c 2019 |
| 520 | a Recent research focusing on brown adipose tissue (BAT) function emphasizes its importance in systemic metabolic homeostasis. We show here that genetic and pharmacological inhibition of the mevalonate pathway leads to reduced human and mouse brown adipocyte function in vitro and impaired adipose tissue browning in vivo. A retrospective analysis of a large patient cohort suggests an inverse correlation between statin use and active BAT in humans, while we show in a prospective clinical trial that fluvastatin reduces thermogenic gene expression in human BAT. We identify geranylgeranyl pyrophosphate as the key mevalonate pathway intermediate driving adipocyte browning in vitro and in vivo, whose effects are mediated by geranylgeranyltransferases (GGTases), enzymes catalyzing geranylgeranylation of small GTP-binding proteins, thereby regulating YAP1/TAZ signaling through F-actin modulation. Conversely, adipocyte-specific ablation of GGTase I leads to impaired adipocyte browning, reduced energy expenditure, and glucose intolerance under obesogenic conditions, highlighting the importance of this pathway in modulating brown adipocyte functionality and systemic metabolism. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 653 | a adipose-tissue | |
| 653 | a energy-expenditure | |
| 653 | a glucose-uptake | |
| 653 | a oxidative-metabolism | |
| 653 | a insulin sensitivity | |
| 653 | a statins | |
| 653 | a differentiation | |
| 653 | a thermogenesis | |
| 653 | a expression | |
| 653 | a farnesol | |
| 700 | 1 | a Becker, A. S.4 aut |
| 700 | 1 | a Balazova, L.4 aut |
| 700 | 1 | a Straub, L.4 aut |
| 700 | 1 | a Muller, J.4 aut |
| 700 | 1 | a Gashi, G.4 aut |
| 700 | 1 | a Maushart, C. I.4 aut |
| 700 | 1 | a Sun, W. F.4 aut |
| 700 | 1 | a Dong, H.4 aut |
| 700 | 1 | a Moser, C.4 aut |
| 700 | 1 | a Horvath, C.4 aut |
| 700 | 1 | a Efthymiou, V.4 aut |
| 700 | 1 | a Rachamin, Y.4 aut |
| 700 | 1 | a Modica, S.4 aut |
| 700 | 1 | a Zellweger, C.4 aut |
| 700 | 1 | a Bacanovic, S.4 aut |
| 700 | 1 | a Stefanicka, P.4 aut |
| 700 | 1 | a Varga, L.4 aut |
| 700 | 1 | a Ukropcova, B.4 aut |
| 700 | 1 | a Profant, M.4 aut |
| 700 | 1 | a Opitz, L.4 aut |
| 700 | 1 | a Amri, E. Z.4 aut |
| 700 | 1 | a Akula, Murali Ku Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center4 aut |
| 700 | 1 | a Bergö, Martin,d 1970u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center4 aut0 (Swepub:gu)xbmarl |
| 700 | 1 | a Ukropec, J.4 aut |
| 700 | 1 | a Falk, C.4 aut |
| 700 | 1 | a Zamboni, N.4 aut |
| 700 | 1 | a Betz, M. J.4 aut |
| 700 | 1 | a Burger, I. A.4 aut |
| 700 | 1 | a Wolfrum, C.4 aut |
| 710 | 2 | a Göteborgs universitetb Sahlgrenska Cancer Center4 org |
| 773 | 0 | t Cell Metabolismd : Elsevier BVg 29:4q 29:4x 1550-4131x 1932-7420 |
| 856 | 4 | u http://www.cell.com/article/S1550413118307368/pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/279810 |
| 856 | 4 8 | u https://doi.org/10.1016/j.cmet.2018.11.017 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140608782 |
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