Sökning: onr:"swepub:oai:gup.ub.gu.se/280068" > Genetic Determinant...
Fältnamn | Indikatorer | Metadata |
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000 | 05981naa a2201177 4500 | |
001 | oai:gup.ub.gu.se/280068 | |
003 | SwePub | |
008 | 240910s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2800682 URI |
024 | 7 | a https://doi.org/10.1210/jc.2017-020602 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Eriksson, Anna-Lena,d 1971u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xeannj |
245 | 1 0 | a Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men. |
264 | c 2018-01-09 | |
264 | 1 | b The Endocrine Society,c 2018 |
520 | a Serum estradiol (E2) and estrone (E1) levels exhibit substantial heritability.To investigate the genetic regulation of serum E2 and E1 in men.Genome-wide association study in 11,097 men of European origin from nine epidemiological cohorts.Genetic determinants of serum E2 and E1 levels.Variants in/near CYP19A1 demonstrated the strongest evidence for association with E2, resolving to three independent signals. Two additional independent signals were found on the X chromosome; FAMily with sequence similarity 9, member B (FAM9B), rs5934505 (P = 3.4 × 10-8) and Xq27.3, rs5951794 (P = 3.1 × 10-10). E1 signals were found in CYP19A1 (rs2899472, P = 5.5 × 10-23), in Tripartite motif containing 4 (TRIM4; rs17277546, P = 5.8 × 10-14), and CYP11B1/B2 (rs10093796, P = 1.2 × 10-8). E2 signals in CYP19A1 and FAM9B were associated with bone mineral density (BMD). Mendelian randomization analysis suggested a causal effect of serum E2 on BMD in men. A 1 pg/mL genetically increased E2 was associated with a 0.048 standard deviation increase in lumbar spine BMD (P = 2.8 × 10-12). In men and women combined, CYP19A1 alleles associated with higher E2 levels were associated with lower degrees of insulin resistance.Our findings confirm that CYP19A1 is an important genetic regulator of E2 and E1 levels and strengthen the causal importance of E2 for bone health in men. We also report two independent loci on the X-chromosome for E2, and one locus each in TRIM4 and CYP11B1/B2, for E1. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a Aromatase | |
653 | a genetics | |
653 | a Bone Density | |
653 | a genetics | |
653 | a physiology | |
653 | a Chromosomes | |
653 | a Human | |
653 | a X | |
653 | a Cohort Studies | |
653 | a Estradiol | |
653 | a blood | |
653 | a genetics | |
653 | a physiology | |
653 | a Estrone | |
653 | a blood | |
653 | a genetics | |
653 | a Female | |
653 | a Gene Expression Regulation | |
653 | a physiology | |
653 | a Genome-Wide Association Study | |
653 | a Genotype | |
653 | a Gonadal Steroid Hormones | |
653 | a blood | |
653 | a Humans | |
653 | a Insulin Resistance | |
653 | a genetics | |
653 | a physiology | |
653 | a Lumbar Vertebrae | |
653 | a physiology | |
653 | a Male | |
653 | a Mendelian Randomization Analysis | |
653 | a Polymorphism | |
653 | a Single Nucleotide | |
653 | a Testosterone | |
653 | a blood | |
700 | 1 | a Perry, John R B4 aut |
700 | 1 | a Coviello, Andrea D4 aut |
700 | 1 | a Delgado, Graciela E4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Hoffman, Andrew R4 aut |
700 | 1 | a Huhtaniemi, Ilpo T4 aut |
700 | 1 | a Ikram, M Arfan4 aut |
700 | 1 | a Karlsson, Magnus K4 aut |
700 | 1 | a Kleber, Marcus E4 aut |
700 | 1 | a Laughlin, Gail A4 aut |
700 | 1 | a Liu, Yongmei4 aut |
700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xlomat |
700 | 1 | a Lunetta, Kathryn L4 aut |
700 | 1 | a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xmelda |
700 | 1 | a Murabito, Joanne M4 aut |
700 | 1 | a Murray, Anna4 aut |
700 | 1 | a Nethander, Maria,d 1980u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xnetma |
700 | 1 | a Nielson, Carrie M4 aut |
700 | 1 | a Prokopenko, Inga4 aut |
700 | 1 | a Pye, Stephen R4 aut |
700 | 1 | a Raffel, Leslie J4 aut |
700 | 1 | a Rivadeneira, Fernando4 aut |
700 | 1 | a Srikanth, Priya4 aut |
700 | 1 | a Stolk, Lisette4 aut |
700 | 1 | a Teumer, Alexander4 aut |
700 | 1 | a Travison, Thomas G4 aut |
700 | 1 | a Uitterlinden, André G4 aut |
700 | 1 | a Vaidya, Dhananjay4 aut |
700 | 1 | a Vanderschueren, Dirk4 aut |
700 | 1 | a Zmuda, Joseph M4 aut |
700 | 1 | a März, Winfried4 aut |
700 | 1 | a Orwoll, Eric S4 aut |
700 | 1 | a Ouyang, Pamela4 aut |
700 | 1 | a Vandenput, Liesbeth,d 1974u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xvanli |
700 | 1 | a Wu, Frederick C W4 aut |
700 | 1 | a de Jong, Frank H4 aut |
700 | 1 | a Bhasin, Shalender4 aut |
700 | 1 | a Kiel, Douglas P4 aut |
700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xohlcl |
710 | 2 | a Göteborgs universitetb Centre for Bone and Arthritis Research4 org |
773 | 0 | t Journal of Clinical Endocrinology and Metabolismd : The Endocrine Societyg 103:3, s. 991-1004q 103:3<991-1004x 0021-972Xx 1945-7197 |
856 | 4 | u https://academic.oup.com/jcem/article-pdf/103/3/991/24262721/jc.2017-02060.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/280068 |
856 | 4 8 | u https://doi.org/10.1210/jc.2017-02060 |
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