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Immunohistochemical...
Immunohistochemical examination of P-cadherin in bullous and acantholytic skin diseases.
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- Kovács, Anikó, 1961 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology
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Schmidt, Emese (författare)
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Bégány, Agnes (författare)
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Hunyadi, János (författare)
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Szegedi, Andrea (författare)
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(creator_code:org_t)
- Medical Journals Sweden AB, 2004
- 2004
- Engelska.
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Ingår i: Acta dermato-venereologica. - : Medical Journals Sweden AB. - 0001-5555. ; 84:2, s. 116-9
- Relaterad länk:
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Autoimmune blistering diseases (pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, dermatitis herpetiformis) and certain genodermatoses with acantholysis (Darier-disease, Hailey-Hailey disease) have different aetiological factors, but all result in bulla formation and/or in acantholysis. Cadherins are Ca++-dependent cell-cell adhesion molecules which play an important role in the cellular connection between normal cells. P-cadherin is involved in the selective adhesion of epidermal cells, and is expressed only on the surfaces of the two basal layers. We examined the expression of P-cadherin in some autoimmune bullous skin diseases and Darier's disease using immunohistochemistry and found P-cadherin to be strongly upregulated. We believe the upregulation is compensatory to the primary pathophysiological events in the various bullous dermatoses.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Nyckelord
- Acantholysis
- immunology
- pathology
- Biomarkers
- analysis
- Biopsy
- Needle
- Cadherins
- analysis
- metabolism
- Darier Disease
- immunology
- pathology
- Female
- Humans
- Immunohistochemistry
- Male
- Microscopy
- Immunoelectron
- Pemphigoid
- Bullous
- immunology
- pathology
- Pemphigus
- immunology
- pathology
- Reference Values
- Sampling Studies
- Sensitivity and Specificity
- Severity of Illness Index
- Skin Diseases
- Vesiculobullous
- immunology
- pathology
- Up-Regulation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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