Sökning: onr:"swepub:oai:gup.ub.gu.se/282023" > High throughput pro...
Fältnamn | Indikatorer | Metadata |
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000 | 04332naa a2200613 4500 | |
001 | oai:gup.ub.gu.se/282023 | |
003 | SwePub | |
008 | 240528s2019 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-388611 | |
024 | 7 | a https://gup.ub.gu.se/publication/2820232 URI |
024 | 7 | a https://doi.org/10.1038/s42003-019-0464-92 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3886112 URI |
040 | a (SwePub)gud (SwePub)uu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Enroth, Stefan,d 1976-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Gyllensten4 aut0 (Swepub:uu)stenr451 |
245 | 1 0 | a High throughput proteomics identifies a high-accuracy 11 plasma protein biomarker signature for ovarian cancer |
264 | c 2019-06-20 | |
264 | 1 | b Springer Science and Business Media LLC,c 2019 |
500 | a These authors contributed equally: Stefan Enroth, Malin Berggrund | |
520 | a Ovarian cancer is usually detected at a late stage and the overall 5-year survival is only 30-40%. Additional means for early detection and improved diagnosis are acutely needed. To search for novel biomarkers, we compared circulating plasma levels of 593 proteins in three cohorts of patients with ovarian cancer and benign tumors, using the proximity extension assay (PEA). A combinatorial strategy was developed for identification of different multivariate biomarker signatures. A final model consisting of 11 biomarkers plus age was developed into a multiplex PEA test reporting in absolute concentrations. The final model was evaluated in a fourth independent cohort and has an AUC = 0.94, PPV = 0.92, sensitivity = 0.85 and specificity = 0.93 for detection of ovarian cancer stages I-IV. The novel plasma protein signature could be used to improve the diagnosis of women with adnexal ovarian mass or in screening to identify women that should be referred to specialized examination. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a multiple linear-regression | |
653 | a folate receptor-alpha | |
653 | a he-4 | |
653 | a size | |
653 | a expression | |
653 | a matriptase | |
653 | a malignancy | |
653 | a prognosis | |
653 | a models | |
653 | a target | |
653 | a Life Sciences & Biomedicine | |
653 | a Diagnostic markers | |
700 | 1 | a Berggrund, Malinu Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)malbe459 |
700 | 1 | a Lycke, Mariau Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xlycma |
700 | 1 | a Broberg, J.4 aut |
700 | 1 | a Lundberg, M.4 aut |
700 | 1 | a Assarsson, E.4 aut |
700 | 1 | a Olovsson, Matts,d 1958-u Uppsala universitet,Reproduktionsbiologi4 aut0 (Swepub:uu)mattolov |
700 | 1 | a Stålberg, Karinu Uppsala universitet,Reproduktiv hälsa4 aut0 (Swepub:uu)kariglim |
700 | 1 | a Sundfeldt, Karin,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xsukar |
700 | 1 | a Gyllensten, Ulf B.u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik4 aut0 (Swepub:uu)ulfgyll |
710 | 2 | a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 org |
773 | 0 | t Communications Biologyd : Springer Science and Business Media LLCg 2q 2x 2399-3642 |
856 | 4 | u https://www.nature.com/articles/s42003-019-0464-9.pdf |
856 | 4 | u https://doi.org/10.1038/s42003-019-0464-9y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1334275/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/282023 |
856 | 4 8 | u https://doi.org/10.1038/s42003-019-0464-9 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-388611 |
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