Sökning: onr:"swepub:oai:gup.ub.gu.se/283687" > Mitochondrial prote...
Fältnamn | Indikatorer | Metadata |
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000 | 04143naa a2200529 4500 | |
001 | oai:gup.ub.gu.se/283687 | |
003 | SwePub | |
008 | 240910s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2836872 URI |
024 | 7 | a https://doi.org/10.1080/20013078.2019.16354202 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Jang, Su Chul,d 1984u Gothenburg University,Göteborgs universitet,Krefting Research Centre4 aut0 (Swepub:gu)xjangs |
245 | 1 0 | a Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma |
264 | c 2019-08-27 | |
264 | 1 | b Wiley,c 2019 |
520 | a Extracellular vesicles (EVs), including exosomes and microvesicles, are secreted from all cells, and convey messages between cells in health and disease. However, the diversity of EV subpopulations is only beginning to be explored. Since EVs have been implicated in tumour microenvironmental communication, we started to determine the diversity of EVs specifically in this tissue. To do this, we isolated EVs directly from patient melanoma metastatic tissues. Using EV membrane isolation and mass spectrometry analysis, we discovered enrichment of mitochondrial membrane proteins in the melanoma tissue-derived EVs, compared to non-melanoma-derived EVs. Interestingly, two mitochondrial inner membrane proteins MT-CO2 (encoded by the mitochondrial genome) and COX6c (encoded by the nuclear genome) were highly prevalent in the plasma of melanoma patients, as well as in ovarian and breast cancer patients. Furthermore, this subpopulation of EVs contains active mitochondrial enzymes. In summary, tumour tissues are enriched in EVs with mitochondrial membrane proteins and these mitochondrial membrane proteins can be detected in plasma and are increased in melanoma, ovarian cancer as well as breast cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Extracellular vesicles | |
653 | a melanoma | |
653 | a membrane proteins | |
653 | a mitochondria | |
653 | a cancer-cells | |
653 | a exosomes | |
653 | a membrane | |
653 | a identification | |
653 | a biogenesis | |
653 | a proteomics | |
653 | a markers | |
653 | a Cell Biology | |
700 | 1 | a Crescitelli, Rossella,d 1985u Gothenburg University,Göteborgs universitet,Krefting Research Centre4 aut0 (Swepub:gu)xcrero |
700 | 1 | a Cvjetkovic, Aleksanderu Gothenburg University,Göteborgs universitet,Krefting Research Centre4 aut0 (Swepub:gu)xcvjal |
700 | 1 | a Belgrano, Valeriou Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery4 aut0 (Swepub:gu)xbelgv |
700 | 1 | a Olofsson Bagge, Roger,d 1978u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery4 aut0 (Swepub:gu)xoloro |
700 | 1 | a Sundfeldt, Karin,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Sahlgrenska Cancer Center,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xsukar |
700 | 1 | a Ochiya, T.4 aut |
700 | 1 | a Kalluri, R.4 aut |
700 | 1 | a Lötvall, Jan,d 1956u Gothenburg University,Göteborgs universitet,Krefting Research Centre4 aut0 (Swepub:gu)xlotja |
710 | 2 | a Göteborgs universitetb Krefting Research Centre4 org |
773 | 0 | t Journal of Extracellular Vesiclesd : Wileyg 8:1q 8:1x 2001-3078 |
856 | 4 | u https://www.tandfonline.com/doi/pdf/10.1080/20013078.2019.1635420?needAccess=true |
856 | 4 8 | u https://gup.ub.gu.se/publication/283687 |
856 | 4 8 | u https://doi.org/10.1080/20013078.2019.1635420 |
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