SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:gup.ub.gu.se/286277"
 

Sökning: onr:"swepub:oai:gup.ub.gu.se/286277" > Longitudinal Cortic...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003969naa a2200409 4500
001oai:gup.ub.gu.se/286277
003SwePub
008240528s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:142683369
0247 a https://gup.ub.gu.se/publication/2862772 URI
0247 a https://doi.org/10.1016/j.biopsych.2019.08.0152 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1426833692 URI
040 a (SwePub)gud (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Abé, Christophu Karolinska Institutet4 aut
2451 0a Longitudinal Cortical Thickness Changes in Bipolar Disorder and the Relationship to Genetic Risk, Mania, and Lithium Use.
264 1b Elsevier BV,c 2020
520 a Bipolar disorder (BD) is a highly heritable psychiatric disorder characterized by episodes of manic and depressed mood states and associated with cortical brain abnormalities. Although the course of BD is often progressive, longitudinal brain imaging studies are scarce. It remains unknown whether brain abnormalities are static traits of BD or result from pathological changes over time. Moreover, the genetic effect on implicated brain regions remains unknown.Patients with BD and healthy control (HC) subjects underwent structural magnetic resonance imaging at baseline (123 patients, 83 HC subjects) and after 6 years (90 patients, 61 HC subjects). Cortical thickness maps were generated using FreeSurfer. Using linear mixed effects models, we compared longitudinal changes in cortical thickness between patients with BD and HC subjects across the whole brain. We related our findings to genetic risk for BD and tested for effects of demographic and clinical variables.Patients showed abnormal cortical thinning of temporal cortices and thickness increases in visual/somatosensory brain areas. Thickness increases were related to genetic risk and lithium use. Patients who experienced hypomanic or manic episodes between time points showed abnormal thinning in inferior frontal cortices. Cortical changes did not differ between diagnostic BD subtypes I and II.In the largest longitudinal BD study to date, we detected abnormal cortical changes with high anatomical resolution. We delineated regional effects of clinical symptoms, genetic factors, and medication that may explain progressive brain changes in BD. Our study yields important insights into disease mechanisms and suggests that neuroprogression plays a role in BD.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
7001 a Liberg, Benny4 aut
7001 a Song, Jieu Karolinska Institutet4 aut
7001 a Bergen, Sarah Eu Karolinska Institutet4 aut
7001 a Petrovic, Predragu Karolinska Institutet4 aut
7001 a Ekman, Carl Johanu Karolinska Institutet4 aut
7001 a Sellgren, Carl Mu Karolinska Institutet4 aut
7001 a Ingvar, Martinu Karolinska Institutet4 aut
7001 a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt
7102 a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
7730 t Biological psychiatryd : Elsevier BVg 87:3, s. 271-281q 87:3<271-281x 1873-2402x 0006-3223
8564 u http://www.biologicalpsychiatryjournal.com/article/S0006322319316270/pdf
8564 8u https://gup.ub.gu.se/publication/286277
8564 8u https://doi.org/10.1016/j.biopsych.2019.08.015
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:142683369

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy