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Cell-of-origin dete...
Cell-of-origin determined by both gene expression profiling and immunohistochemistry is the strongest predictor of survival in patients with diffuse large B-cell lymphoma
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- Abdulla, Maysaa (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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- Hollander, Peter (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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- Pandzic, Tatjana (författare)
- Uppsala universitet,Medicinsk genetik och genomik
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- Mansouri, L. (författare)
- Karolinska Institutet
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- Ednersson, S. B. (författare)
- Sahlgrens Univ Hosp, Dept Pathol, Gothenburg, Sweden
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- Andersson, Per-Ola, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden;Sodra Alvsborg Hosp Borås, Dept Med, Borås, Sweden
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- Hultdin, Magnus (författare)
- Umeå universitet,Patologi,Umeå Univ, Dept Med Biosci, Pathol, Umeå, Sweden
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- Fors, M. (författare)
- Umeå universitet,Patologi,Umeå Univ, Dept Med Biosci, Pathol, Umeå, Sweden
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- Erlanson, Martin (författare)
- Umeå universitet,Onkologi,Umeå Univ, Dept Radiat Sci, Oncol, Umeå, Sweden
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- Degerman, Sofie, 1977- (författare)
- Umeå universitet,Patologi,Umeå Univ, Dept Med Biosci, Pathol, Umeå, Sweden
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- Petersen, H. M. (författare)
- Copenhagen Univ Hosp, Dept Pathol, Rigshosp, Copenhagen, Denmark
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- Asmar, F. (författare)
- Copenhagen Univ Hosp, Dept Hematol, Rigshosp, Copenhagen, Denmark
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- Gronbaek, K. (författare)
- Copenhagen Univ Hosp, Dept Hematol, Rigshosp, Copenhagen, Denmark
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- Enblad, G. (författare)
- Uppsala Univ, Expt & Clin Oncol, Dept Immunol Genet & Pathol, Uppsala, Sweden
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- Cavelier, Lucia (författare)
- Uppsala universitet,Medicinsk genetik och genomik
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- Rosenquist, R. (författare)
- Karolinska Institutet
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- Amini, Rose-Marie (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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(creator_code:org_t)
- 2019-11-07
- 2020
- Engelska.
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Ingår i: American Journal of Hematology. - : Wiley. - 0361-8609 .- 1096-8652. ; 95:1, s. 57-67
- Relaterad länk:
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https://onlinelibrar...
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visa fler...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The tumor cells in diffuse large B-cell lymphomas (DLBCL) are considered to originate from germinal center derived B-cells (GCB) or activated B-cells (ABC). Gene expression profiling (GEP) is preferably used to determine the cell of origin (COO). However, GEP is not widely applied in clinical practice and consequently, several algorithms based on immunohistochemistry (IHC) have been developed. Our aim was to evaluate the concordance of COO assignment between the Lymph2Cx GEP assay and the IHC-based Hans algorithm, to decide which model is the best survival predictor. Both GEP and IHC were performed in 359 homogenously treated Swedish and Danish DLBCL patients, in a retrospective multicenter cohort. The overall concordance between GEP and IHC algorithm was 72%; GEP classified 85% of cases assigned as GCB by IHC, as GCB, while 58% classified as non-GCB by IHC, were categorized as ABC by GEP. There were significant survival differences (overall survival and progression-free survival) if cases were classified by GEP, whereas if cases were categorized by IHC only progression-free survival differed significantly. Importantly, patients assigned as non-GCB/ABC both by IHC and GEP had the worst prognosis, which was also significant in multivariate analyses. Double expression of MYC and BCL2 was more common in ABC cases and was associated with a dismal outcome. In conclusion, to determine COO both by IHC and GEP is the strongest outcome predictor to identify DLBCL patients with the worst outcome.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- rituximab plus cyclophosphamide
- molecular subtypes
- classification
- vincristine
- doxorubicin
- myc
- immunochemotherapy
- impact
- bcl2
- Patologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Abdulla, Maysaa
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Hollander, Peter
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Pandzic, Tatjana
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Mansouri, L.
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Ednersson, S. B.
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Andersson, Per-O ...
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visa fler...
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Hultdin, Magnus
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Fors, M.
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Erlanson, Martin
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Degerman, Sofie, ...
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Petersen, H. M.
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Asmar, F.
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Gronbaek, K.
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Enblad, G.
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Cavelier, Lucia
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Rosenquist, R.
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Amini, Rose-Mari ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Klinisk laborato ...
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- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Uppsala universitet
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Karolinska Institutet