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Comparative analysi...
Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum.
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- Rohin Rajan, Meenu (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Centre for Molecular and Translational Medicine,Wallenberg Laboratory,Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden; Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden
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- Sotak, Matus (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Centre for Molecular and Translational Medicine,Wallenberg Laboratory,Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Cell & Molecular Biology, Uppsala University, Uppsala, Sweden,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden; Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden
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- Barrenäs, Fredrik, 1981 (författare)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Wallenberglaboratoriet,Wallenberg Laboratory,Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden,Beräkningsbiologi och bioinformatik,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden; Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden,Univ Gothenburg, Sweden; Uppsala Univ, Sweden
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- Shen, Tong (författare)
- NIH West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, USA,Univ Calif Davis, NIH West Coast Metabol Ctr, Genome Ctr, Davis, CA 95616 USA
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- Borkowski, Kamil (författare)
- NIH West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, USA,Univ Calif Davis, NIH West Coast Metabol Ctr, Genome Ctr, Davis, CA 95616 USA
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- Ashton, Nicholas J. (författare)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Psychiatry and Neurochemistry, Institute of Physiology and Neuroscience, University of Gothenburg, Gothenburg, Sweden; King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK; NIHR Biomedical Research Centre for Mental Health & Biomedical Research Unit for Dementia at South London & Maudsley NHS Foundation, London, UK,Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden;Univ Gothenburg, Inst Physiol & Neurosci, Dept Psychiat & Neurochem, Gothenburg, Sweden;Kings Coll London, Inst Psychiat Psychol & Neurosci, Maurice Wohl Clin Neurosci Inst, London, England;NIHR Biomed Res Ctr Mental Hlth, London, England;Biomed Res Unit Dementia South London, London, England;Maudsley NHS Fdn, London, England
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- Biörserud, Christina (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education,Department of Gastrosurgical Research and Education, Institute of Clinical Sciences, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Gastrosurg Res & Educ, Gothenburg, Sweden
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- Lindahl, Tomas (författare)
- Linköpings universitet,Avdelningen för klinisk kemi,Medicinska fakulteten,Region Östergötland, Klinisk kemi
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- Ramström, Sofia, 1973- (författare)
- Linköpings universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Chemistry and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden,Cardiovascular Research Centre,Linkoping Univ, Dept Clin Chem, Linkoping, Sweden;Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden;Orebro Univ, Cardiovasc Res Ctr, Sch Med Sci, Orebro, Sweden,Avdelningen för klinisk kemi,Medicinska fakulteten,Region Östergötland, Klinisk kemi
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- Schöll, Michael, 1980 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Psychiatry and Neurochemistry, Institute of Physiology and Neuroscience, University of Gothenburg, Gothenburg, Sweden; Dementia Research Centre, Institute of Neurology, University College London, London, UK,Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden;Univ Gothenburg, Inst Physiol & Neurosci, Dept Psychiat & Neurochem, Gothenburg, Sweden;UCL, Dementia Res Ctr, Inst Neurol, London, England
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- Lindahl, Per, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin,Wallenberg Laboratory,Institute of Medicine,Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden
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- Fiehn, Oliver (författare)
- NIH West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, USA,Univ Calif Davis, NIH West Coast Metabol Ctr, Genome Ctr, Davis, CA 95616 USA
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- Newman, John W (författare)
- NIH West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, USA; Department of Nutrition, University of California Davis, Davis, USA; USDA, ARS, Western Human Nutrition Research Center, Davis, USA,Univ Calif Davis, NIH West Coast Metabol Ctr, Genome Ctr, Davis, CA 95616 USA;Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA;ARS, USDA, Western Human Nutr Res Ctr, Davis, CA USA
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- Perkins, Rosie, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden
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- Wallenius, Ville, 1970 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Gastrosurgical Research and Education, Institute of Clinical Sciences, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Gastrosurg Res & Educ, Gothenburg, Sweden
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- Lange, Stephan (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Division of Cardiology, School of Medicine, University of California San Diego, San Diego, USA,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden;Univ Calif San Diego, Sch Med, Div Cardiol, San Diego, CA 92103 USA
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- Börgeson, Emma (författare)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Wallenberglaboratoriet,Wallenberg Laboratory,Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden;Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden;Sahlgrens Univ Hosp, Dept Clin Physiol, Gothenburg, Sweden
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(creator_code:org_t)
- 2019-10-28
- 2019
- Engelska.
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1
- Relaterad länk:
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https://www.nature.c...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://liu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The search for biomarkers associated with obesity-related diseases is ongoing, but it is not clear whether plasma and serum can be used interchangeably in this process. Here we used high-throughput screening to analyze 358 proteins and 76 lipids, selected because of their relevance to obesity-associated diseases, in plasma and serum from age- and sex-matched lean and obese humans. Most of the proteins/lipids had similar concentrations in plasma and serum, but a subset showed significant differences. Notably, a key marker of cardiovascular disease PAI-1 showed a difference in concentration between the obese and lean groups only in plasma. Furthermore, some biomarkers showed poor correlations between plasma and serum, including PCSK9, an important regulator of cholesterol homeostasis. Collectively, our results show that the choice of biofluid may impact study outcome when screening for obesity-related biomarkers and we identify several markers where this will be the case.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Nyckelord
- Biomarkers
- obesity
- cardiometabolic disease
- Olink
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Rohin Rajan, Mee ...
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Sotak, Matus
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Barrenäs, Fredri ...
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Shen, Tong
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Borkowski, Kamil
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Ashton, Nicholas ...
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visa fler...
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Biörserud, Chris ...
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Lindahl, Tomas
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Ramström, Sofia, ...
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Schöll, Michael, ...
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Lindahl, Per, 19 ...
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Fiehn, Oliver
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Newman, John W
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Perkins, Rosie, ...
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Wallenius, Ville ...
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Lange, Stephan
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Börgeson, Emma
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Klinisk laborato ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Läkemedelskemi
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Göteborgs universitet
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Örebro universitet
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