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Concomitant use of ...
Concomitant use of pembrolizumab and entinostat in adult patients with metastatic uveal melanoma (PEMDAC study): protocol for a multicenter phase II open label study.
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- Jespersen, Henrik (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Oncol,Sahlgrenska Acad, Bla Straket 2, S-41345 Gothenburg, Sweden,Sahlgrenska University Hospital
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- Olofsson Bagge, Roger, 1978 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Surg,Sahlgrenska Acad, Bla Straket 5, S-41345 Gothenburg, Sweden,Sahlgrenska University Hospital
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- Ullenhag, Gustav (författare)
- Uppsala University,Uppsala universitet,Experimentell och klinisk onkologi
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- Carneiro, Ana (författare)
- Lund University,Lunds universitet,Skåne University Hospital
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- Helgadottir, Hildur (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Ljuslinder, Ingrid (författare)
- Norrlands Univ Hosp, Dept Oncol, S-90185 Umea, Sweden,Norrland University Hospital
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- Levin, Max, 1969 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Oncol,Sahlgrenska Acad, Bla Straket 2, S-41345 Gothenburg, Sweden,Sahlgrenska University Hospital
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- All-Eriksson, Charlotta (författare)
- St Erik Eye Hosp, Polhemsgatan 50, S-11230 Stockholm, Sweden,St Erik Eye Hospital
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- Andersson, Bengt (författare)
- Sahlgrens Univ Hosp, Dept Clin Immunol & Transfus Med, Guldhedsgatan 10, S-41345 Gothenburg, Sweden,Sahlgrenska University Hospital
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- Stierner, Ulrika, 1952 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Oncol,Sahlgrenska Acad, Bla Straket 2, S-41345 Gothenburg, Sweden,Sahlgrenska University Hospital
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- Nilsson, Lisa M, 1976 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Univ Gothenburg, Sahlgrenska Univ Hosp, Sahlgrenska Canc Ctr, Sahlgrenska Acad, Med Aregatan 1F, S-40530 Gothenburg, Sweden,Sahlgrenska University Hospital
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- Nilsson, Jonas A, 1971 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Sahlgrenska Cancer Center,Institute of Clinical Sciences, Department of Surgery,Univ Gothenburg, Sahlgrenska Univ Hosp, Sahlgrenska Canc Ctr, Sahlgrenska Acad, Med Aregatan 1F, S-40530 Gothenburg, Sweden,Sahlgrenska University Hospital
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- Ny, Lars, 1967 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Oncol,Sahlgrenska Acad, Bla Straket 2, S-41345 Gothenburg, Sweden,Sahlgrenska University Hospital
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(creator_code:org_t)
- 2019-05-02
- 2019
- Engelska.
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Ingår i: BMC cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 19:1
- Relaterad länk:
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https://bmccancer.bi...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- While recent years have seen a revolution in the treatment of metastatic cutaneous melanoma, no treatment has yet been able to demonstrate any prolonged survival in metastatic uveal melanoma. Thus, metastatic uveal melanoma remains a disease with an urgent unmet medical need. Reports of treatment with immune checkpoint inhibitors have thus far been disappointing. Based on animal experiments, it is reasonable to hypothesize that the effect of immunotherapy may be augmented by epigenetic therapy. Proposed mechanisms include enhanced expression of HLA class I and cancer antigens on cancer cells, as well as suppression of myeloid suppressor cells.The PEMDAC study is a multicenter, open label phase II study assessing the efficacy of concomitant use of the PD1 inhibitor pembrolizumab and the class I HDAC inhibitor entinostat in adult patients with metastatic uveal melanoma. Primary endpoint is objective response rate. Eligible patients have histologically confirmed metastatic uveal melanoma, ECOG performance status 0-1, measurable disease as per RECIST 1.1 and may have received any number of prior therapies, with the exception of anticancer immunotherapy. Twenty nine patients will be enrolled. Patients receive pembrolizumab 200mg intravenously every third week in combination with entinostat 5mg orally once weekly. Treatment will continue until progression of disease or intolerable toxicity or for a maximum of 24months.The PEMDAC study is the first trial to assess whether the addition of an HDAC inhibitor to anti-PD1 therapy can yield objective anti-tumoral responses in metastatic UM.ClinicalTrials.gov registration number: NCT02697630 . (Registered 3 March 2016). EudraCT registration number: 2016-002114-50.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Administration
- Intravenous
- Administration
- Oral
- Antibodies
- Monoclonal
- Humanized
- administration & dosage
- therapeutic use
- Antineoplastic Combined Chemotherapy Protocols
- administration & dosage
- therapeutic use
- Benzamides
- administration & dosage
- therapeutic use
- Drug Administration Schedule
- Female
- Humans
- Male
- Melanoma
- drug therapy
- Prospective Studies
- Pyridines
- administration & dosage
- therapeutic use
- Research Design
- Treatment Outcome
- Uveal Neoplasms
- drug therapy
- Uveal melanoma
- Entinostat
- Epigenetics
- Histone deacetylase inhibitors
- Immunotherapy
- Metastatic
- Pembrolizumab
- Programmed cell death 1 receptor
- Uveal melanoma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Jespersen, Henri ...
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Olofsson Bagge, ...
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Ullenhag, Gustav
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Carneiro, Ana
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Helgadottir, Hil ...
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Ljuslinder, Ingr ...
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visa fler...
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Levin, Max, 1969
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All-Eriksson, Ch ...
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Andersson, Bengt
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Stierner, Ulrika ...
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Nilsson, Lisa M, ...
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Nilsson, Jonas A ...
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Ny, Lars, 1967
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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BMC cancer
- Av lärosätet
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Göteborgs universitet
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Uppsala universitet
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Karolinska Institutet
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Lunds universitet