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Complex I is bypass...
Complex I is bypassed during high intensity exercise
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- Nilsson, Avlant, 1985 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Gothenburg, Sweden
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- Björnson, Elias, 1988 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Gothenburg, Sweden
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- Flockhart, Mikael (författare)
- Gymnastik- och idrottshögskolan,Åstrandlaboratoriet
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- Larsen, Filip J, 1977- (författare)
- Gymnastik- och idrottshögskolan,Forskningsgruppen Mitokondriell funktion och metabol kontroll
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- Nielsen, Jens B, 1962 (författare)
- Danmarks Tekniske Universitet,Technical University of Denmark,Chalmers tekniska högskola,Chalmers University of Technology,Novo Nordisk Fonden,Novo Nordisk Foundation,Chalmers University of Technology, Gothenburg, Sweden
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(creator_code:org_t)
- 2019-11-07
- 2019
- Engelska.
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
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Abstract
Ämnesord
Stäng
- Human muscles are tailored towards ATP synthesis. When exercising at high work rates muscles convert glucose to lactate, which is less nutrient efficient than respiration. There is hence a trade-off between endurance and power. Metabolic models have been developed to study how limited catalytic capacity of enzymes affects ATP synthesis. Here we integrate an enzyme-constrained metabolic model with proteomics data from muscle fibers. We find that ATP synthesis is constrained by several enzymes. A metabolic bypass of mitochondrial complex I is found to increase the ATP synthesis rate per gram of protein compared to full respiration. To test if this metabolic mode occurs in vivo, we conduct a high resolved incremental exercise tests for five subjects. Their gas exchange at different work rates is accurately reproduced by a whole-body metabolic model incorporating complex I bypass. The study therefore shows how proteome allocation influences metabolism during high intensity exercise.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- human skeletal-muscle
- lactate metabolism
- efficiency
- atp
- carbohydrate
- performance
- rates
- Medicin/Teknik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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