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Recurrence rates af...
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Sundberg, JonasGothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, Gothenburg, Sweden.
(författare)
Recurrence rates after surgical removal of oral leukoplakia-A prospective longitudinal multi-centre study.
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-12-06
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Public Library of Science (PLoS),2019
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/287805
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https://gup.ub.gu.se/publication/287805URI
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https://doi.org/10.1371/journal.pone.0225682DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-413864URI
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Oral leukoplakia (OL) is a potentially malignant oral disorder. The Gold Standard treatment is to remove surgically the OL. Despite optimal surgery, the recurrence rates are estimated to be 30%. The reason for this is unknown. The aim of this study was to investigate the clinical factors that correlate with recurrence after surgical removal of OL. In a prospective study data were collected from 226 patients with OL. Forty-six patients were excluded due to incomplete records or concomitant presence of other oral mucosal diseases. Overall, 180 patients proceeded to analysis (94 women and 86 men; mean age, 62 years; age range, 28-92 years). Clinical data, such as gender, diagnosis (homogeneous/non-homogeneous leukoplakia), location, size, tobacco and alcohol use, verified histopathological diagnosis, and clinical photograph, were obtained. In patients who were eligible for surgery, the OL was surgically removed with a margin. To establish recurrence, a healthy mucosa between the surgery and recurrence had to be confirmed in the records or clinical photographs. Statistical analysis was performed with the level of significance set at P<0.05. Of the 180 patients diagnosed with OL, 57% (N = 103) underwent surgical removal in toto. Recurrence was observed in 43 OL. The cumulative incidence of recurrence of OL was 45% after 4 years and 49% after 5 years. Fifty-six percent (N = 23) of the non-homogeneous type recurred. Among snuff-users 73% (N = 8) cases of OL recurred. A non-homogeneous type of OL and the use of snuff were significantly associated with recurrence after surgical excision (P = 0.021 and P = 0.003, respectively). Recurrence was also significantly associated with cancer transformation (P<0.001). No significant differences were found between recurrence and any of the following: dysplasia, site of lesion, size, multiple vs. solitary OL, gender, age, use of alcohol or smoking. In conclusion, clinical factors that predict recurrence of OL are non-homogeneous type and use of snuff.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Korytowska, MagdalenaNAL Hosp, Clin Orofacial Med, Trollhattan, Region Vastra G, Sweden.
(författare)
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Holmberg, Erik,1951Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg, Sweden.(Swepub:gu)xholer
(författare)
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Bratel, JohnClin Oral Med, Gothenburg, Region Vastra G, Sweden.
(författare)
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Wallström, MatsClin Oral & Maxillofacial Surg, Gothenburg, Region Vastra G, Sweden.
(författare)
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Kjellström, EbbaUppsala universitet,Käkkirurgi
(författare)
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Blomgren, JohanSahlgrenska Univ Hosp East, Clin Oral Med, Gothenburg, Region Vastra G, Sweden.
(författare)
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Kovács, AnikóSahlgrens Univ Hosp, Dept Clin Pathol, Gothenburg, Sweden.
(författare)
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Öhman, JennyGothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, Gothenburg, Sweden.(Swepub:gu)xohmje
(författare)
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Sand, LarsUniv Oslo, Fac Odontol, Dept Oral Biol, Oslo, Norway.
(författare)
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Hirsch, Jan-MichaelUppsala universitet,Käkkirurgi(Swepub:uu)jahir257
(författare)
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Giglio, Daniel,1977Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg, Sweden.(Swepub:gu)xgigda
(författare)
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Kjeller, GöranGothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Clin Oral & Maxillofacial Surg, Gothenburg, Region Vastra G, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral & Maxillofacial Surg, Gothenburg, Sweden.(Swepub:gu)xzelgr
(författare)
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Hasséus, Bengt,1955Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, Gothenburg, Sweden.;Clin Oral Med, Gothenburg, Region Vastra G, Sweden.(Swepub:gu)xhasbe
(författare)
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Göteborgs universitetInstitutionen för odontologi
(creator_code:org_t)
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Ingår i:PloS one: Public Library of Science (PLoS)14:121932-6203
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Sundberg, Jonas
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Korytowska, Magd ...
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Holmberg, Erik, ...
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Bratel, John
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Wallström, Mats
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Kjellström, Ebba
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Blomgren, Johan
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Kovács, Anikó
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Öhman, Jenny
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Sand, Lars
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Hirsch, Jan-Mich ...
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Giglio, Daniel, ...
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Kjeller, Göran
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Hasséus, Bengt, ...
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